Document Detail


Evaluation of osmotic effects on coated pellets using a mechanistic model.
MedLine Citation:
PMID:  17161565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to develop a simple experimental methodology and to develop a mechanistic model to characterize the release mechanism from pellets developing cracks during the release process with special focus on osmotic effects. The release of remoxipride from pellets coated with an ethyl cellulose film was chosen as a case study. Dose release experiments at different bulk osmotic pressures revealed that the release process was mainly osmotically driven. The model was used to calculate the solvent permeability of the coating, 1.1 x 10(-10)m(2)h(-1)MPa(-1). The model was validated by release experiments using similar pellets having different coating thicknesses. The effective diffusion coefficient of remoxipride in the coating was also calculated and found to be 1.7 x 10(-10)m(2)h(-1). A series of experiments was performed in which the osmotic pressure of the receiving solution was changed during the experiment. From the results of these experiments, the area of the cracks in the film, formed by the hydrostatic pressure built up inside the pellets, was estimated to be 3.5 x 10(-5)m(2)/m(2) coating. It could also be deduced that the solvent permeability of the coating film was affected by swelling in the same way at different osmotic pressures.
Authors:
Mariagrazia Marucci; Gert Ragnarsson; Anders Axelsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-17
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  336     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-16     Completed Date:  2007-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  IM    
Affiliation:
Department of Chemical Engineering, Lund University, PO Box 124, SE-221 00 Lund, Sweden. mariagraziam@chemeng.lth.se
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Cellulose / analogs & derivatives,  chemistry
Citrates / chemistry
Diffusion
Glucose / chemistry
Models, Chemical*
Osmolar Concentration
Osmotic Pressure
Permeability
Pharmaceutical Preparations / administration & dosage,  chemistry*
Remoxipride / administration & dosage,  chemistry,  pharmacokinetics
Tablets, Enteric-Coated / chemistry*
Time Factors
Water / chemistry
Chemical
Reg. No./Substance:
0/Citrates; 0/Pharmaceutical Preparations; 0/Tablets, Enteric-Coated; 50-99-7/Glucose; 77-93-0/ethyl citrate; 7732-18-5/Water; 80125-14-0/Remoxipride; 9004-34-6/Cellulose; 9004-57-3/ethyl cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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