| Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique. | |
| | |
MedLine Citation:
|
PMID: 21303918 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background Oesophageal intraluminal impedance is currently used for assessment of reflux in gastro-oesophageal reflux disease (GORD). Oesophageal mucosa integrity may have a key role in heartburn perception in non-erosive reflux disease (NERD). Severe erosive oesophagitis is associated with low impedance baseline. We hypothesised that impedance baseline measurements could be used to evaluate changes in oesophageal mucosa integrity in man. Methods We measured oesophageal impedance baseline before, during and after acid perfusion in rabbits and healthy subjects. Transepithelial resistance (TER) was determined and dilated intercellular spaces (DIS) were assessed in isolated rabbit oesophageal mucosa. Impedance baseline was measured retrospectively at different levels of the oesophagus in impedance-pH recordings from asymptomatic volunteers and patients with GORD. Results In healthy subjects and rabbits, impedance baseline dropped dramatically during perfusion of control solution (pH 7.2) but after perfusion, impedance recovered. In rabbits, after perfusion with saline pH 1.5 and 1.0 impedance values remained a 39.1±7.0% and 63.9±6.5% (p<0.05) lower respectively. There was a positive correlation between in vivo basal impedance and in vitro TER values (r=0.72, p=0.0021). Tissue showed no erosions but both acidic solutions induced DIS. In healthy subjects, after perfusion with saline pH 2.0 and 1.0 the impedance baseline remained lower a 21.9±6.5% and 52.7±5.0%, (p<0.0001) respectively. Patients with GORD have a lower impedance baseline than healthy volunteers at the distal oesophagus. Conclusions Impedance baseline measurements might be used to evaluate the status of the oesophageal mucosa and to study the role of the impaired mucosal integrity in acid-induced heartburn in healthy volunteers and in patients with GORD. |
| | |
Authors:
|
Ricard Farré; Kathleen Blondeau; Dominique Clement; Maria Vicario; Lucia Cardozo; Michael Vieth; Veerle Mertens; Ans Pauwels; Jiri Silny; Marcel Jimenez; Jan Tack; Daniel Sifrim |
Related Documents
:
|
2874908 - Thyroidal response to an increase or decrease of endogenous tsh in patients with hypert... 9007698 - Evaluation of central motor conduction in hypothyroid and hyperthyroid patients. 20857158 - Polymyositis associated with hypothyroidism or hyperthyroidism: two cases and review of... 1713218 - Plasma free triiodothyronine response to thyrotropin-releasing hormone to predict the r... 22078218 - Outcome after repair of cor triatriatum. 16921078 - A rural emergency medical retrieval service: the first year. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-8 |
Journal Detail:
|
Title: Gut Volume: - ISSN: 1468-3288 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985108R Medline TA: Gut Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Catholic University Leuven, Leuven, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A population-based comparison of the survival of patients with colorectal cancer in England, Norway ...
Next Document: Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces ...