Document Detail

Evaluation of ocular tumors with technetium-99m-MIBI: planar pinhole technique or SPECT?
MedLine Citation:
PMID:  10824618     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study compares 2 imaging protocols, planar pinhole technique (PPHT) and SPECT, for evaluating ocular masses with 99mTc-MIBI. METHODS: Sixteen patients with ocular lesions were studied. Planar images were acquired 10 min after the injection of 740 MBq 99mTc-MIBI with an LFOV camera fitted with a pinhole collimator (5.0 mm). A SPECT study was performed immediately after the planar study, using a 360 degrees orbit, 64 steps, 20 s/stop, a 128 x 128 matrix, and a low-energy high-resolution (LEHR) collimator. Twelve lesions (9.5-18.0 mm) proved to be malignant: 8 primary tumors (ocular melanoma); 3 local relapses of different tumors of the conjunctiva; and 1 ocular metastasis from breast cancer. The remaining 4 lesions (10.0-16.0 mm) were benign: 1 inflammatory lesion; 1 benign intraocular calcification; and 2 naevi. RESULTS: SPECT images showed 11 of 12 malignant lesions (91.6%), whereas the planar technique demonstrated only 4 of the 12 lesions (33.3%). One false-positive result, the inflammatory lesion, was visualized by both techniques. The remaining benign lesions were not detected with either method. CONCLUSION: Technetium-99m-MIBI SPECT is a sensitive technique for detecting malignant ocular tumors. SPECT imaging is a better alternative to planar imaging for ocular tumors.
O Alonso; M Núñez; J Cánepa; P Guisoli; F Mut; G Lago; E Touya
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine technology     Volume:  28     ISSN:  0091-4916     ISO Abbreviation:  J Nucl Med Technol     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-20     Completed Date:  2000-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0430303     Medline TA:  J Nucl Med Technol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-7     Citation Subset:  IM    
Nuclear Medicine Center of the Clinical Hospital and School of Medical Technology, University of Uruguay, Montevideo.
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MeSH Terms
Aged, 80 and over
Breast Neoplasms / pathology
Calcinosis / radionuclide imaging
Conjunctival Neoplasms / radionuclide imaging
Equipment Design
Eye Diseases / radionuclide imaging
Eye Neoplasms / radionuclide imaging*,  secondary
False Positive Reactions
Gamma Cameras*
Image Processing, Computer-Assisted / instrumentation,  methods
Melanoma / radionuclide imaging
Middle Aged
Neoplasm Recurrence, Local / radionuclide imaging
Nevus / radionuclide imaging
Radiopharmaceuticals / diagnostic use*
Sensitivity and Specificity
Technetium Tc 99m Sestamibi / diagnostic use*
Tomography, Emission-Computed / instrumentation,  methods
Tomography, Emission-Computed, Single-Photon* / methods
Uveitis / radionuclide imaging
Reg. No./Substance:
0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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