| Evaluation of nystatin stability using tristimulus colorimetry. | |
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MedLine Citation:
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PMID: 7205586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A tristimulus reflectance spectrophotometer was used to examine the color changes of nystatin during accelerated stability studies, and a relationship was observed between the loss of microbiological potency and the change in color during thermal degradation. By substitution of the measured tristimulus values in the Kubelka-Munk equation, the remission function was calculated and resulted in a linear response with time. Application of the technique to bulk raw materials and formulated products is demonstrated, and uses of the technique are discussed. |
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Authors:
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J E Fairbrother; W F Heyes; G Clarke; P R Wood |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 69 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1980 Jun |
Date Detail:
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Created Date: 1981-05-26 Completed Date: 1981-05-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 697-700 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Colorimetry Drug Stability Hot Temperature Nystatin* Time Factors |
| Chemical | |
Reg. No./Substance:
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1400-61-9/Nystatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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