Document Detail


Evaluation of nystatin stability using tristimulus colorimetry.
MedLine Citation:
PMID:  7205586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A tristimulus reflectance spectrophotometer was used to examine the color changes of nystatin during accelerated stability studies, and a relationship was observed between the loss of microbiological potency and the change in color during thermal degradation. By substitution of the measured tristimulus values in the Kubelka-Munk equation, the remission function was calculated and resulted in a linear response with time. Application of the technique to bulk raw materials and formulated products is demonstrated, and uses of the technique are discussed.
Authors:
J E Fairbrother; W F Heyes; G Clarke; P R Wood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  69     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  697-700     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Colorimetry
Drug Stability
Hot Temperature
Nystatin*
Time Factors
Chemical
Reg. No./Substance:
1400-61-9/Nystatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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