Document Detail

Evaluation of a nystatin-containing mouth rinse for terminally ill patients in palliative care.
MedLine Citation:
PMID:  12955925     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the antifungal effect of a nystatin mouth rinse to control oral candidiasis of elderly patients in palliative care. MATERIALS AND METHODS: 52 cancer patients (mean age: 83 years) hospitalized in a long term care facility for chronically ill geriatric patients. Mouth rinsing with 15 ml nystatin solution (4,000 Ul/ml) was carried out for one minute, six times daily, over two weeks. Yeasts were collected and seeded on CHROMagar. Growth was read qualitatively and quantitatively after two days' incubation at 37 degrees C. RESULTS: Clinical signs of oral candidiasis were observed in 31% of cases. High yeast scores were observed in 58% of the residents. There was an association between signs of oral candidiasis and high yeast scores (p < 0.001). Treatment for two weeks caused no clinical changes nor reduced yeast scores. CONCLUSIONS: No clinical or antifungal effect from the nystatin suspension suggests that the concentration of nystatin in the mouth rinse was too low. A more effective procedure should be employed for antifungal treatment of terminally ill patients. Appropriate antimicrobial solutions with lubricating activity should be developed and applied to prevent oral diseases.
Gaël Butticaz; Gilbert B Zulian; Marie Preumont; Ejvind Budtz-Jørgensen
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of palliative care     Volume:  19     ISSN:  0825-8597     ISO Abbreviation:  J Palliat Care     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-05     Completed Date:  2003-11-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610345     Medline TA:  J Palliat Care     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
Division of Gerodontology and Removable Prosthodontics, University of Geneva, Geneva, Switzerland.
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MeSH Terms
Aged, 80 and over
Antifungal Agents / therapeutic use*
Candidiasis, Oral / drug therapy*,  etiology
Chi-Square Distribution
Colony Count, Microbial
Neoplasms / complications
Nystatin / therapeutic use*
Terminally Ill*
Treatment Outcome
Reg. No./Substance:
0/Antifungal Agents; 0/Mouthwashes; 1400-61-9/Nystatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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