Document Detail

Evaluation of a novel (18)F-labeled positron-emission tomography perfusion tracer for the assessment of myocardial infarct size in rats.
MedLine Citation:
PMID:  19808572     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The goal of this study was to evaluate a new (18)F-labeled positron-emission tomography (PET) perfusion tracer, (18)F BMS747158-02, for the assessment of myocardial infarct (MI) size. METHODS AND RESULTS: Wistar rats were studied 24 hours after ligation of the left coronary artery either permanently (n=15) or transiently (n=16) for 30 minutes. Seven nonoperated rats were studied as controls. The rats were injected with 37 MBq of (18)F BMS747158-02 and imaged with a small animal PET scanner for 20 minutes. Polar maps were generated for measurement of PET defect size, and left ventricular systolic and diastolic volumes were assessed in gated images. As a reference, MI size was determined by 2,3,5-triphenyltetrazolium chloride staining of left ventricular tissue samples. Permanent or transient ligation of the left coronary artery produced transmural or subendocardial MI of variable sizes, respectively. In normal rats, PET imaging demonstrated intense and homogeneous uptake of (18)F BMS747158-02 throughout the myocardium. After ligation, sharply defined perfusion defects were present. Throughout the imaging period, the defect size correlated closely with the MI size either after permanent (r=0.88; P<0.01; mean difference, 1.86%) or transient (r=0.92; P<0.01; mean difference, 2.16%) ligation of the left coronary artery. Moreover, reduction of left ventricular systolic function measured with PET correlated with the MI size (r=-0.81; P<0.01; n=23). CONCLUSIONS: Myocardial (18)F BMS747158-02 PET imaging provides excellent image quality and uptake properties, enabling accurate evaluation of MI size and left ventricular function in rats. It is a promising technique for evaluation of MI size in clinical trials.
Hossam M Sherif; Antti Saraste; Eliane Weidl; Axel W Weber; Takahiro Higuchi; Sybille Reder; Thorsten Poethko; Gjermund Henriksen; David Casebier; Simon Robinson; Hans-Jürgen Wester; Stephan G Nekolla; Markus Schwaiger
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-26
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  2     ISSN:  1942-0080     ISO Abbreviation:  Circ Cardiovasc Imaging     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-10-07     Completed Date:  2009-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
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MeSH Terms
Fluorine Radioisotopes / diagnostic use*
Heart / radionuclide imaging
Image Processing, Computer-Assisted
Myocardial Infarction / pathology,  radionuclide imaging*
Myocardial Perfusion Imaging
Myocardium / pathology
Positron-Emission Tomography*
Pyridazines / diagnostic use*
Radiopharmaceuticals / diagnostic use*
Rats, Wistar
Reg. No./Substance:
0/BMS 747158-02; 0/Fluorine Radioisotopes; 0/Pyridazines; 0/Radiopharmaceuticals
Comment In:
Circ Cardiovasc Imaging. 2009 Mar;2(2):75-6   [PMID:  19808571 ]

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