| Evaluation of nonradioactive, colored microspheres for measurement of regional myocardial blood flow in dogs. | |
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MedLine Citation:
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PMID: 3396179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Measurement of regional myocardial blood flow (RMBF) is crucial in experimental studies of myocardial ischemia and reperfusion in dogs. The standard measurement technique uses radioactive microspheres; however, not all institutions are able to dispose of radioactive waste and therefore cannot make use of this method. We tested a new, nonradioactive microsphere, labeled with colors instead of nuclides. Simultaneous blood flow measurements with two nuclide-labeled and two colored microspheres were performed after coronary occlusion in dogs. Both techniques show a within-method correlation of r greater than 0.98. Duplicate variability for paired RMBF values in 80 samples was 8.7 +/- 0.1% when computed with radioactive microspheres and 13.2 +/- 1.8% when computed with colored microspheres. There was a good correlation in the measurement of RMBF between the radioactive- and colored-microsphere methods (r = 0.98). The best-fitting linear regression line was expressed by the formula: Colored-microsphere RMBF = 1.11 (radioactive-microsphere RMBF)-0.02. When measured by colored microspheres, RMBF was approximately 8% higher than when computed with radioactive microspheres for blood flow values of 0-2 ml/min/g. When blood flow was increased pharmacologically to levels of 2-7.5 ml/min/g, colored microspheres yielded blood flow values 39% higher than the values computed by radioactive microspheres. We conclude that the nonradioactive, colored-microsphere method correlates with the radioactive technique, but at high flows, it yields values greater than those obtained with radioactive microspheres. |
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Authors:
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S L Hale; K J Alker; R A Kloner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 78 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-08-31 Completed Date: 1988-08-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 428-34 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerium Radioisotopes / diagnostic use Color Coronary Circulation* Coronary Disease / physiopathology Dogs Female Heart Rate Male Microspheres* Niobium / diagnostic use Radioisotopes / diagnostic use Ruthenium Radioisotopes / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Cerium Radioisotopes; 0/Radioisotopes; 0/Ruthenium Radioisotopes; 7440-03-1/Niobium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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