| Evaluation of noninvasive methods for the estimation of haemoglobin content in red blood cell concentrates. | |
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MedLine Citation:
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PMID: 21143671 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: Red blood cell concentrates (RCCs) are the major blood component transfused to patients. There is a great variability in patient response, depending on both the patient's blood volume and haemoglobin content in the RCC. Standardisation of transfusion practice is needed to improve the prediction of patient outcome. Aim: We hypothesise that labelling of RCCs with haemoglobin content will add possibilities for the standardisation of transfusion practice. Methods: Data from multiple international transfusion services regarding haemoglobin content and weight or volume of RCC were collected and analysed. Results: We demonstrate a strong and highly significant correlation between haemoglobin content with both weight and volume of the RCCs. A linear regression model was used to assess these relationships, and it demonstrates how haemoglobin content can be estimated for different cell production processes. Conclusions: We recommend the use of weight or volume of the RCCs as the basis of estimating haemoglobin in the RCC and postulate that this can be used in future studies to explore the effects of a haemoglobin dose-based transfusion system. As the weight - and sometimes the volume - of the blood bag is easily accessible, in contrast to direct haemoglobin measurements from each individual unit, this method is feasible and simple. |
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Authors:
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H Reikvam; L Van De Watering; C Prowse; D Devine; N M Heddle; T Hervig |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-12 |
Journal Detail:
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Title: Transfusion medicine (Oxford, England) Volume: - ISSN: 1365-3148 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301182 Medline TA: Transfus Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2010 The Authors. Transfusion Medicine © 2010 British Blood Transfusion Society. |
Affiliation:
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Department of Haematology, Institute of Internal Medicine, University of Bergen, Bergen, Norway Department of Research and Development, Sanquin Blood Supply, Leiden, The Netherlands National Science Laboratory, Scottish National Blood Transfusion Service, Edinburgh, UK Canadian Blood Services and University of British Columbia Centre for Blood Research, Vancouver, British Columbia, Canada Department of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Immunology and Transfusion Medicine, Haukeland University Hospital and the Gade Institute University of Bergen, Bergen, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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