| Evaluation of noncirrhotic hepatic parenchyma with and without significant portal vein stenosis using diffusion-weighted echo-planar MR on the basis of multiple-perfusion-components theory. | |
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MedLine Citation:
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PMID: 20833499 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To determine whether diffusion-weighted echo-planar MR images are sensitive to liver perfusion difference. Noncirrhotic livers of 71 patients (43 males, 28 females; age range, 22-87 years; mean, 61 years) without (n=51) and with (n=20) significant (>70%) portal vein stenosis (accompanying proximal hepatic arterial stenosis and/or biliary tract obstruction in 10) by tumors were examined with diffusion-weighted echo-planar sequences (modified for b factors of 1, 28, 66, 288 and 600 s/mm(2)). On the basis of multiple-perfusion-components theory, i.e., assuming logarithm of signal intensity for liver perfusion is linearly attenuated versus logarithm of a smaller b factor, we defined the slope of the line as the perfusion-related D' value. The D' values of these livers were calculated from images with b factors of 1, 28, and 66 s/mm(2). The livers' apparent diffusion coefficient values for diffusion (ADC(d) values) were calculated from images with b factors of 288 and 600 s/mm(2). The livers with significant portal vein stenosis had statistically lower mean D' values than the livers without portal vein stenosis (P<.001 on the Mann-Whitney U test). However, there was no significant difference in ADC(d) values between these liver types (P>.05). The D' value calculated from diffusion-weighted echo-planar sequences with plural smaller b factors may be sensitive to liver perfusion difference. |
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Authors:
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Takao Moteki; Hiroyuki Horikoshi |
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Publication Detail:
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Type: Journal Article Date: 2010-09-15 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 29 ISSN: 1873-5894 ISO Abbreviation: Magn Reson Imaging Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: Netherlands |
Other Details:
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Languages: eng Pagination: 64-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiology, Fujioka General Hospital, Gunma 375-8503, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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