Document Detail


Evaluation of non-invasive techniques to assess vasoconstriction in healthy volunteers using methoxamine as a probe drug.
MedLine Citation:
PMID:  8933997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Non-invasive methods for assessment of the vascular effects of antimigraine drugs were evaluated with respect to their utility, variability and sensitivity in a double-blind, placebo-controlled, three-period crossover study in six healthy volunteers using an intravenous vasoconstrictor, methoxamine, as a probe drug. Changes in the internal diameter of the brachial and radial arteries were measured using ultrasound which had low between-day and within-day coefficients of variation. Peak systolic velocity (PSV), time-averaged velocity (TAV), total flow, resistance (RI) and pulsatility indices (PI) were measured by Doppler from one arterial wave form. Whilst PSV and TAV increased with methoxamine, because of bradycardia, changes in PI and RI were difficult to interpret. An automatic oscillometric cuff, a mercury-in-silastic strain gauge method and the "Finapres", finger arterial blood pressure monitor were used to follow changes in systolic blood pressure (SBP). The strain gauge technique underestimated arm SBP compared to the oscillometric method but clearly showed drug-related increases whilst the Finapres did not reflect changes in blood pressure detected by the other methods.
Authors:
R M Dixon; H B Meire; C Leigh; J Posner; P E Rolan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  16     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-18     Completed Date:  1997-02-18     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  507-17     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure
Brachial Artery / physiology*,  ultrasonography
Cardiography, Impedance
Cross-Over Studies
Double-Blind Method
Female
Hemodynamics*
Humans
Male
Methoxamine / administration & dosage,  diagnostic use*
Migraine Disorders / drug therapy,  physiopathology
Radial Artery / physiology*,  ultrasonography
Ultrasonography, Doppler
Vasoconstriction
Vasoconstrictor Agents / administration & dosage,  diagnostic use*
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 390-28-3/Methoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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