|Evaluation of a new pocket echoscopic device for focused-cardiac ultrasonography in emergency setting.|
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|ABSTRACT: INTRODUCTION: In the emergency setting, focused cardiac ultrasound has become a fundamental tool for diagnostic, initiate emergency treatment and triage decisions. A new ultra-miniaturized pocket ultrasound device (PUD) may be suited in this specific setting. Therefore, we aimed to compare the diagnostic ability of an ultra-miniaturized ultrasound device (VscanTM, GE Healthcare, Wauwatosa, WI) and of a conventional high-quality echocardiography system (Vivid S5TM, GE Healthcare) for a cardiac focused ultrasonography in patients admitted in emergency department. METHODS: During 4 months, patients admitted to our emergency department and requiring transthoracic echocardiography (TTE) were included in this single-center, prospective and observational study. Patients underwent TTE using pocket ultrasound device (PUD) and conventional echocardiography system. Each examination was performed independently by a physician experienced in echocardiography, unaware of the results found by the alternative device. During the focused cardiac echocardiography, the following parameters were assessed: global cardiac systolic function, identification of ventricular enlargement or hypertrophy, assessment for pericardial effusion and estimation of the size and the respiratory changes of the inferior vena cava (IVC) diameter. RESULTS: One hundred and fifty one (151) patients were analysed. Using the tested PUD, the image quality was sufficient to perform focused cardiac ultrasonography in all patients. Examination using PUD adequately qualified with a very good agreement global left ventricular systolic dysfunction (kappa=0.87; 95%CI: 0.76-0.97), severe right ventricular dilation (kappa=0.87; 95%CI: 0.71-1.00), inferior vena cava dilation (kappa=0.90; 95%CI: 0.80-1.00), respiratory induced variations in inferior vena cava size in spontaneous breathing (kappa=0.84; 95%CI: 0.71-0.98), pericardial effusion (kappa=0.75; 95%CI: 0.55-0.95) and compressive pericardial effusion (kappa=1.00; 95%CI: 1.00-1.00). CONCLUSIONS: In emergency setting, this new ultraportable echoscope was reliable for the real-time detection of focused cardiac abnormalities.|
|Matthieu Biais; Cedric Carrie; Francois Delaunay; Nicolas Morel; Philippe Revel; Gerard Janvier|
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|Type: JOURNAL ARTICLE Date: 2012-5-14|
|Title: Critical care (London, England) Volume: 16 ISSN: 1466-609X ISO Abbreviation: - Publication Date: 2012 May|
|Created Date: 2012-5-15 Completed Date: - Revised Date: -|
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|Nlm Unique ID: 9801902 Medline TA: Crit Care Country: -|
|Languages: ENG Pagination: R82 Citation Subset: -|
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Journal ID (nlm-ta): Crit Care
Journal ID (iso-abbrev): Crit Care
Publisher: BioMed Central
Copyright ©2012 Biais et al.; licensee BioMed Central Ltd.
Received Day: 4 Month: 1 Year: 2012
Revision Received Day: 16 Month: 4 Year: 2012
Accepted Day: 14 Month: 5 Year: 2012
Print publication date: Year: 2012
Electronic publication date: Day: 14 Month: 5 Year: 2012
Volume: 16 Issue: 3
First Page: R82 Last Page: R82
PubMed Id: 22583539
Publisher Id: cc11340
|Evaluation of a new pocket echoscopic device for focused cardiac ultrasonography in an emergency setting|
|Matthieu Biais12||Email: firstname.lastname@example.org|
|Cédric Carrié1||Email: email@example.com|
|François Delaunay1||Email: firstname.lastname@example.org|
|Nicolas Morel1||Email: email@example.com|
|Philippe Revel1||Email: firstname.lastname@example.org|
|Gérard Janvier12||Email: email@example.com|
1Emergency Department, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Place Amélie Raba Léon, F-33076 Bordeaux Cedex, France
2Université Bordeaux Segalen, Rue Léo Saignat, F-33076, Bordeaux Cedex, France
The widespread use of emergency echocardiography provides valuable assistance in the management of acutely ill patients, allowing fast and accurate assessment of cardiac function and the ability to determine the cause of hemodynamic disorders [1-4]. Because standard echocardiographic equipment may be heavy and difficult to handle, hand-carried ultrasound (US) devices have been developed for bedside use, facilitating the growth of point-of-care ultrasonography . When used by adequately trained intensivists, these devices have a well-demonstrated reliability and a widespread availability and rapid diagnostic capability, ideally suited for the emergency setting [6-8]. However, confusion between focused and comprehensive US among the many types of hand-carried US devices must be avoided [9-11]. Pocket devices are not able to perform a complete echocardiographic examination but can provide accurate diagnoses based on two-dimensional imaging for effective bedside screening. They can be used as an extension of the physical examination in various clinical settings, underlining the concept of personal echoscope. They have been shown to directly guide and alter clinical management and have a therapeutic impact equivalent to that of standard echocardiography [12-15].
Recently, a new generation of ultra-miniaturized US devices - the Vscan™ (GE Healthcare, Wauwatosa, WI, USA) - has been developed. Its true portability, ease of use, and relative low cost make this device adequately suited for routine use in strategies of focused US examination. At present, only a few studies evaluating its feasibility and clinical usefulness have been published [16-20]. However, none of them has compared its diagnostic accuracy with that of standard echocardiography in emergency settings. Thus, the main purpose of this study was to evaluate the recently available pocket US device (PUD) in comparison with standard transthoracic echocardiography (TTE) for focused cardiac ultrasonography in the emergency setting.
During a 4-month period (from February to May 2011), all patients who were admitted to our emergency department and who required a TTE were included, unless two investigators were both unavailable. The following variables were collected at enrolment: demographic data, reason for admission (medical or surgical), medical history, cardio-respiratory status, Simplified Acute Physiology Score II (SAPS II), and indication for performing the US exam. Indications for TTE were left to the discretion of the attending physician but should be focused on a clinical problem or evaluation of patients with cardiac history (Table 1). This prospective, single-center, and observational study was approved by the local ethics committee (Comité de Protection des Personnes Sud-Ouest et Outre Mer III, Bordeaux, France; protocol DC 2011/07), which waived the need for informed consent. Patients or next of kin were orally informed of the goal and design of the study.
Each eligible patient was subsequently examined by two different echocardiography systems: the tested PUD (Vscan™; GE Healthcare) and a conventional echographic system (Vivid S5™; GE Healthcare). The new PUD, designed to be operated with one hand, consisted of a 135 × 73 × 28 mm unit connected to a 1.7 to 3.8 MHz phased array transducer (total weight of 390 g). Autonomy, battery fully charged, was 1 hour. The technical capabilities of the PUD allowed diagnosis based only on two-dimensional imaging and allowed possible adjustments of global gain and depth. Color flow mode was available, but there were no advanced features such as the M-mode or pulsed and continuous Doppler mode. Images could be frozen and stored for review.
Each examination was performed independently by two intensivists - MB and CC, who are experienced in echocardiography and have level II competence (as assessed by the European Association of Echocardiography) in general adult TTE - in random order within a 30-minute time frame. Both investigators were provided with medical history and clinical and paraclinical exams of the patient but were unaware of the results found by the alternative echocardiography device.
As recommended for focused cardiac examination in emergency patients , parameters recorded by using the PUD were the assessment of global cardiac systolic function, the identification of ventricular enlargement or hypertrophy, the assessment for a pericardial effusion, and the visual estimation of the size and respiratory changes of the inferior vena cava (IVC) diameter. Each clinical question was recorded by using a qualitative approach considered positive, negative, or undetermined (no response when the imaging quality or the device technology failed to provide a definite diagnosis). Only left ventricular ejection fraction (LVEF) was estimated by using a quantitative and visual approach.
For the purpose of this study, the systematic examination using conventional TTE was considered the reference diagnostic method to measure each variable, as recommended by the European Association of Echocardiography . LVEF was calculated by the Simpson method unless it was impossible to obtain and then estimate the ejection fraction by visual approach. Hypertrophy was noticed when the thickness of the interventricular septum exceeded 13 mm, and dilation was noticed when the maximal end-diastolic antero-posterior diameter of the LV cavity was above 55 mm. Right ventricular (RV) dilation was defined by a diastolic ventricular ratio of greater than 0.6 when measured in the apical four-chamber view . IVC diameter was measured proximally in the subcostal view between the right atrial junction and the superior hepatic vein, and a dilation corresponded to an end-expiratory diameter of greater than 23 mm . IVC was considered collapsic if its diameter presented at least a 50% inspiratory decrease in patients with spontaneous ventilation . Pericardial effusion, detected by an echo-free space, was considered compressive in the case of a collapse of the right cavities or respiratory variations of Doppler flow or both.
All echocardiography was interpreted online at bedside. For each US examination, the three standard transthoracic windows (parasternal, apical, and subcostal) were systematically screened. The examination was considered inconclusive when image quality was considered low, data were missing, or not accessible by the visual approach alone. In this case, the corresponding clinical question was not addressed. When all data were collected, duration of the study was measured for each method.
Results are expressed as mean ± standard deviation or median (25% to 75% interquartile range) as appropriate. The results of the PUD and conventional TTE were compared in each patient. Results obtained with the conventional TTE were considered the reference. LVEFs obtained with the two devices were compared by using linear correlation and Bland and Altman analysis . The ability of the PUD to discriminate the severity of the global LV systolic dysfunction (normal was greater than 50%, moderately depressed was 30% to 50%, and severely depressed was less than 30%) was tested by using Cohen's κ coefficient, and 95% confidence intervals (CIs) were calculated . For each other clinical question, data were recorded in order to calculate the sensitivity, specificity, and positive and negative predictive values. The agreement between the clinical responses provided by the two devices was assessed by using Cohen's κ coefficient, and 95% CIs were calculated . Kappa values of less than 0.2 were interpreted as slight, 0.21 to 0.4 as fair, 0.41 to 0.6 as moderate, 0.61 to 0.8 as substantial, and 0.81 to 1.00 as very good agreement . The duration of the exam using the PUD or the conventional approach was compared by using the Wilcoxon test. A P value of less than 0.05 was considered statistically significant.
During the study period, 182 patients admitted to our department underwent a TTE. Among them, 31 patients were not enrolled in the study, because of the absence of at least one investigator. Finally, 151 patients were included. The main characteristics of these patients are shown in Table 1, and indications for TTE are shown in Table 2.
The ability of the PUD to diagnose clinical problems is shown in Table 3, and sensibility, specificity, positive and negative predictive values, and κ coefficient are compared with those of a standardized examination. LVEFs obtained with PUD and with conventional echocardiography were not significantly different (58% ± 13% versus 59% ± 13%, respectively, P > 0.05) and were correlated (r = 0.79, 95% CI 0.72 to 0.84, P < 0.0001) (Figure 1). Comparison between LVEFs obtained with PUD and with conventional TTE showed a mean bias of 1.4% and limits of agreement of -12.2% to 14.9% (Figure 1). The intra-observer reproducibility percentages were 6.6% ± 3.3% using the standard TTE and 2.6% ± 4.2% using the PUD. The inter-observer reproducibility percentages were 6.9% ± 4.3% using standard TTE and 5.5% ± 3.9% using the PUD. Furthermore, examination using PUD adequately qualified the severity of the global LV systolic dysfunction (normal, moderately depressed, or severely depressed) in 134 patients (κ = 0.87, 95% CI 0.76 to 0.97). The presence (or absence) of LV dilation or hypertrophy was adequately classified by PUD, and there was substantial agreement (κ > 0.60). Compared with conventional TTE, PUD adequately identified RV dilation, RV dysfunction, pericardium effusion, and tamponade with good to excellent agreement (range of κ values was 0.63 to 1). Examination using PUD adequately identified the IVC size: empty (κ = 0.86, 95% CI 0.77 to 0.94) or dilated (κ = 0.90, 95% CI 0.80 to 1.00). Respiratory-induced variations in IVC size were well evaluated in spontaneous breathing (κ = 0.84, 95% CI 0.71 to 0.98).
Image quality was good enough to address all clinical questions estimated by visual approach alone without missing data. Compared with conventional TTE exam, the exam using PUD was significantly shorter: 420 seconds (300 to 600) versus 180 seconds (165 to 300), respectively (P < 0.0001).
Our study suggested that, in an emergency setting, the new PUD was reliable for the detection of focused cardiac abnormalities with a good agreement when compared with a last-generation conventional US device. Our results are in accordance with those of previous studies evaluating the diagnostic capabilities of this PUD in other clinical situations. In 100 cardiologic patients in a cardiological setting, Lafitte and colleagues  demonstrated that PUD showed good concordance of diagnostic capability with that of standard full-feature echocardiographic instruments. Prinz and Voigt , who studied 349 consecutive patients from an echocardiography lab, showed a very high image quality, excellent LVEF and LV dimension evaluations, and a good detection of pericardial effusion. In a perioperative setting, Frederiksen and colleagues  confirmed that PUD was well suited for performing a focus-assessed TTE in a surgery setting with a good image quality. More recently, Amiel and colleagues  demonstrated that PUD was able to assess LVEF with a good agreement in 94 critically ill patients.
In emergency or critical care settings, focused US allows findings to be directly correlated with the clinical situation, thereby offsetting the inherent limitations of the physical exam with real-time cardiovascular imaging . Moreover, limited TTE not only provides new information on cardiac function but also may change the initial management of intensive care patients with a similar therapeutic impact thanks to the use of a portable US system compared with a standard US, despite its lower overall diagnostic capacity [13,15]. By increasing the number of clinical diagnoses, PUD could prove cost-effective by decreasing the number of medical errors, providing a more efficient real-time diagnosis, and reducing the use of unnecessary routine US examinations [17,30]. The capability and simplicity of this new PUD make it ideally suited for bedside use in emergency settings, providing time-sensitive assessment to assist physicians in the diagnosis of cardiovascular diseases in addition to the physical examination [31,32]. In fact, it embodies the concept of the visual stethoscope by Galderisi and colleagues , who demonstrated the relevant additional diagnostic power of pocket-size devices in addition to the physical examination. Thanks to a semi-quantitative approach, the device can be used as an echoscopic tool, differing from echocardiography in the lack of quantitative and dedicated measurement tools (that is, area and volume calculations), the absence of flow Doppler capacity, and the inability to provide an extensive report. Recently, a consensus statement by the American Society of Echocardiography/American College of Emergency Physicians emphasized the complementary role of focused cardiac US to that of a more comprehensive echocardiography . The semi-quantitative evaluation of cardiac function by focused US cannot replace a more complete echocardiographic examination but, in some cases, may specify its indications without delaying the immediate management of severe cardiac dysfunction as suspected by the clinical examination.
The smallness of these devices does not preclude the need for full training. Ultrasonography is a user-dependent technology, and as usage spreads, clinicians' skills need to be ensured and the benefits of its appropriate use need to be defined. Most of the recommendations that define skills required in critical care or emergency US also insist on the necessary training required to perform an appropriate examination for a specific purpose [1,4,34]. Furthermore, to apply a systematic diagnostic and therapeutic protocol based on US, all emergency physicians have to be trained in echocardiography, and completing this training can be challenging.
The present study has several limitations. First, the way data were collected was different between the two techniques: we used quantitative measurements with classic US and qualitative assessment with PUD. Consequently, the difference in time consumption was probably explained by the realization of time-specific measures for the evaluation of diameters and ejection fractions with the reference device. Similarly, intra-observer variability assessment was biased by the visual approach, as illustrated by lower intra-observer but similar inter-observer variability. However, the systematic measures using the reference diagnostic method were necessary to confirm that a visual approach alone may be sufficient . Second, we found that the image quality of PUD was sufficient for focused echocardiography, but this does not mean that image quality was similar between the two devices. Third, both PUD and classic TTE were performed by operators experienced in echocardiography and therefore sensitized to a visual assessment of semi-quantitative parameters. We cannot evaluate the relevance of this device if used by an examiner who received minimal training in US. Finally, we evaluated an ultra-miniaturized PUD for focused cardiac ultrasonography in emergency patients but did not assess the impact of this evaluation in terms of diagnostic strategy, treatment, or prognosis.
We showed that, in an emergency setting, a new PUD is reliable for the detection of focused cardiac abnormalities with a good agreement when compared with a last-generation conventional US device. The former device cannot replace a more comprehensive echocardiographic evaluation but can trigger a more precise request without delaying the management of acutely ill patients. However, further methodologically rigorous studies are needed to assess patient-centered outcomes for point-of-care US.
• The image quality of the tested pocket ultrasound device was sufficient to perform focused cardiac ultrasonography in an emergency setting.
• This new pocket ultrasound device is reliable for the detection of focused cardiac abnormalities by a semi-quantitative visual analysis with good agreement.
• Our results should not be extrapolated to comprehensive echocardiography.
• The training necessary to achieve a sufficient level of competence remains to be determined.
CI: confidence interval; IVC: inferior vena cava; LV: left ventricular; LVEF: left ventricular ejection fraction; PUD: pocket ultrasound device; RV: right ventricular; TTE: transthoracic echocardiography; US: ultrasound.
The authors declare that they have no competing interests.
MB helped to conceive the study and design the trial, supervised the conduct of the trial and data collection, and helped to perform all echocardiography, to provide statistical advice on study design, to analyze the data, and to draft the manuscript. CC helped to conceive the study and design the trial, to perform all echocardiography, to provide statistical advice on study design, to analyze the data, and to draft the manuscript. GJ helped to conceive the study and design the trial. NM, FD, and PR helped to undertake recruitment of participating patients. All authors read and approved the final manuscript.
The authors thank Ray Cooke for assistance with manuscript preparation. Only departmental funds were used for this study. No external funds were obtained.
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Main characteristics of a population of 151 patients
|Characteristics of population||Values|
|Age, years||55 ± 20|
|Simplified Acute Physiology Score II||35 ± 18|
|Invasive mechanical ventilation||66 (45)|
|Heart rate, beats per minute||81 ± 20|
|Mean arterial pressure, mm Hg||83 ± 19|
|Patients on norepinephrine support||38 (25)|
|Norepinephrine, μg/kg per minute||0.3 ± 0.3|
|Etiologies of emergency admission|
Data are expressed as mean ± standard deviation or as number (percentage).
Indications for transthoracic echocardiography in a population of 151 patients
|Indications for transthoracic echocardiography||Patients, number (percentage)|
|Systematic or preoperative evaluation in patient with cardiovascular history||49 (32)|
|Hypotension, shock, or postcardiac arrest||38 (25)|
|Chest trauma exploration without respiratory or hemodynamic failure||34 (23)|
|Acute respiratory distress||20 (13)|
|Chest pain||7 (5)|
|Arterial embolism||3 (2)|
Ability of miniaturized echocardiographic system to diagnose clinical problems in a population of 151 patients
|Number of patients||Se, percentage (95% CI)||Sp, percentage (95% CI)||PPV, percentage (95% CI)||NPV, percentage (95% CI)||κ (95% CI)|
|Left ventricular ejection fraction < 50%||28||86 (69-94)||99 (96-100)||96 (80-99)||97 (93-99)||0.89 (0.79-0.98)|
|Left ventricular dilation||8||94 (61-99)||96 (91-98)||57 (32-79)||100 (97-100)||0.70 (0.48-0.93)|
|Left ventricular hypertrophy||26||77 (58-89)||97 (92-99)||83 (64-93)||95 (90-98)||0.76 (0.62-0.90)|
|Right ventricular dilation, cutoff of 0.6||21||59 (39-77)||98 (94-99)||87 (62-96)||93 (87-96)||0.66 (0.47-0.85)|
|Severe right ventricular dilation, cutoff of 1||12||92 (65-98)||99 (95-100)||85 (59-96)||99 (96-100)||0.87 (0.72-1)|
|Pericardial effusion||11||91 (62-89)||96 (92-98)||67 (42-85)||99 (96-100)||0.75 (0.55-0.95)|
|Compressive pericardial effusion||2||100 (34-100)||100 (97-100)||100 (34-100)||100 (97-100)||1 (1-1)|
|Inferior vena cava (IVC)|
|IVC dilation||20||85 (64-96)||100 (97-100)||97 (78-100)||98 (93-99)||0.90 (0.80-1.00)|
|Respiratory variations of IVC size in SB patients||61||97 (89-99)||87 (67-95)||95 (87-98)||91 (71-97)||0.84 (0.71-0.98)|
κ, kappa coefficient; CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value; SB, spontaneously breathing; Se, sensitivity; Sp, specificity.
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