Document Detail


Evaluation of new high-performance calcium polyphosphate bioceramics as bone graft materials.
MedLine Citation:
PMID:  8229417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to evaluate the ability of a recently developed porous calcium polyphosphate bioceramic (CPB) to function as a bone graft substitute. After six weeks, postsurgical extraction of the mandibular first and second molars, alveolar ostectomies were performed bilaterally in five dogs. The ridge forms were then restored using the CPB implant material on one side and the autogenous bone obtained from the contralateral ostectomy site on the other. The graft and implant sites were retrieved after 4 months and decalcified and undecalcified sections were prepared for special staining (modified Attwood) and subsequent light microscopy and histomorphometry. In addition, the undecalcified sections were prepared for histometry using backscattered electron imaging (BSEI). Histologically, the CPB implants showed extensive vascularization and cellularity within an "invading" loose connective tissue matrix. On the opposite side, the loose connective tissue of the autografts showed hypovascularity and hypocellularity. Neither the implants nor the autografts showed any histologic evidence of an inflammatory reaction. Using light microscopic histomorphometry, the implants showed a higher incidence of union than the autografts. On BSEI histometry, the CPB implants showed significantly greater new bone formation than the autografts. This study reveals that porous CPB possesses certain characteristics essential for the "ideal" implantable bone substitute necessary for the repair of craniofacial and other bony defects.
Authors:
S R Nelson; L M Wolford; R J Lagow; P J Capano; W L Davis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  51     ISSN:  0278-2391     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1993-12-20     Completed Date:  1993-12-20     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1363-71     Citation Subset:  AIM; D; IM; S    
Affiliation:
Department of Oral and Maxillofacial Surgery, Baylor College of Dentistry, Dallas, TX.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials
Bone Matrix / transplantation
Bone Transplantation / methods*
Calcium Phosphates*
Ceramics*
Dogs
Male
Microscopy, Electron, Scanning / methods
Osteogenesis
Prostheses and Implants*
Scattering, Radiation
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Calcium Phosphates; 0/Ceramics; 0/alpha-tricalcium phosphate; 0/monocalcium phosphate; 0/tetracalcium phosphate; 97Z1WI3NDX/calcium phosphate; L11K75P92J/dicalcium phosphate anhydrous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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