Document Detail


Evaluation of a new antacid, almagate.
MedLine Citation:
PMID:  6439224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Almagate (Al2Mg6(OH)14(CO3)2 X 4 H2O, Almax), a crystalline hydrated aluminium-magnesium hydroxycarbonate, was compared with a number of other known antacids in a battery of tests designed to demonstrate the properties of an ideal antacid. In dynamic tests for measurement of velocity of neutralization, total acid consuming capacity and duration of activity, almagate like other crystalline aluminium magnesium hydroxide derivatives such as hydrotalcite and magaldrate was rapidly acting, neutralized a high proportion of its theoretical acid consumption and maintained gastric pH between 3 and 5 for a prolonged period of time. It was more active than these two substances in respect of rapidity of action and did not lose antacid activity as the pH was raised. Like these compounds it had considerable advantages over the amorphous gels and co-gels of aluminium and magnesium hydroxides or hydroxycarbonates in respect of both rapidity of action and acid consuming capacity. It inhibited the activity of pepsin and was shown to adsorb bile acids and had a low sodium content.
Authors:
J E Beneyto; J L Fábregas; J Moragues; R G Spickett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  34     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1984  
Date Detail:
Created Date:  1985-01-17     Completed Date:  1985-01-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1350-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adsorption
Aluminum Hydroxide / analysis,  pharmacology*
Antacids / analysis,  pharmacology*
Bile Acids and Salts / analysis
Buffers
Carbonates / analysis,  pharmacology*
Chemical Phenomena
Chemistry
Hydrogen-Ion Concentration
Kinetics
Magnesium / pharmacology*
Magnesium Hydroxide / analysis,  pharmacology*
Pepsin A / antagonists & inhibitors
Sodium / analysis
Chemical
Reg. No./Substance:
0/Antacids; 0/Bile Acids and Salts; 0/Buffers; 0/Carbonates; 1309-42-8/Magnesium Hydroxide; 21645-51-2/Aluminum Hydroxide; 66827-12-1/almagate; 7439-95-4/Magnesium; 7440-23-5/Sodium; EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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