| Evaluation of a new annular capacitance probe for biomass monitoring in industrial pilot-scale fermentations. | |
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MedLine Citation:
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PMID: 15748767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The four-pin electrode capacitance probe has already shown to be a valuable tool for on-line monitoring viable biomass concentration in industrial-type fermentations. A new prototype annular probe was developed and its performance in real-time monitoring the concentration of viable cells during industrial pilot-scale fermentation for the production of an Active Pharmaceutical Ingredient (API) was investigated and compared to the four-pin probe. A set of 14 fermentations was monitored on-line: four of them with the four-pin probe, the remaining with the annular probe. The performance of both the annular and the four-pin electrode probe were compared against each other and against off-line measurements (viscosity and packed mycelial volume). The prototype annular probe showed to have higher signal intensity and sensitivity than the standard four-pin probe, with higher signal-to-noise ratio. Furthermore, its new design and construction proved to be easier to handle in an industrial environment. |
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Authors:
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Ana P Ferreira; Luís M Vieira; Joaquim P Cardoso; José C Menezes |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-01-20 |
Journal Detail:
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Title: Journal of biotechnology Volume: 116 ISSN: 0168-1656 ISO Abbreviation: J. Biotechnol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-07 Completed Date: 2005-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8411927 Medline TA: J Biotechnol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 403-9 Citation Subset: IM |
Affiliation:
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Centre for Biological and Chemical Engineering, IST, Technical University of Lisbon, Av. Rovisco Pais, P-1049-001 Lisbon, Portugal. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bioreactors
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microbiology* Cell Count / instrumentation*, methods Cell Culture Techniques / instrumentation*, methods Cell Proliferation Cell Survival / physiology Electric Capacitance Electrochemistry / instrumentation*, methods Equipment Design Equipment Failure Analysis Fermentation / physiology Industrial Microbiology / instrumentation*, methods Pilot Projects Streptomyces / cytology*, growth & development* Transducers* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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