Document Detail


Evaluation of a new annular capacitance probe for biomass monitoring in industrial pilot-scale fermentations.
MedLine Citation:
PMID:  15748767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The four-pin electrode capacitance probe has already shown to be a valuable tool for on-line monitoring viable biomass concentration in industrial-type fermentations. A new prototype annular probe was developed and its performance in real-time monitoring the concentration of viable cells during industrial pilot-scale fermentation for the production of an Active Pharmaceutical Ingredient (API) was investigated and compared to the four-pin probe. A set of 14 fermentations was monitored on-line: four of them with the four-pin probe, the remaining with the annular probe. The performance of both the annular and the four-pin electrode probe were compared against each other and against off-line measurements (viscosity and packed mycelial volume). The prototype annular probe showed to have higher signal intensity and sensitivity than the standard four-pin probe, with higher signal-to-noise ratio. Furthermore, its new design and construction proved to be easier to handle in an industrial environment.
Authors:
Ana P Ferreira; Luís M Vieira; Joaquim P Cardoso; José C Menezes
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-20
Journal Detail:
Title:  Journal of biotechnology     Volume:  116     ISSN:  0168-1656     ISO Abbreviation:  J. Biotechnol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-07     Completed Date:  2005-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8411927     Medline TA:  J Biotechnol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  403-9     Citation Subset:  IM    
Affiliation:
Centre for Biological and Chemical Engineering, IST, Technical University of Lisbon, Av. Rovisco Pais, P-1049-001 Lisbon, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Bioreactors / microbiology*
Cell Count / instrumentation*,  methods
Cell Culture Techniques / instrumentation*,  methods
Cell Proliferation
Cell Survival / physiology
Electric Capacitance
Electrochemistry / instrumentation*,  methods
Equipment Design
Equipment Failure Analysis
Fermentation / physiology
Industrial Microbiology / instrumentation*,  methods
Pilot Projects
Streptomyces / cytology*,  growth & development*
Transducers*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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