| Evaluation of neuromedin U actions in energy homeostasis and pituitary function. | |
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MedLine Citation:
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PMID: 12239092 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The brain-gut peptide neuromedin U (NMU) has been identified recently as a physiological regulator of food intake. To further investigate the central role of NMU in energy homeostasis, we examined the distribution of NMU transcript and the effect of intracerebroventricular administration on several physiological parameters and on the pattern of c-Fos activation. Here we report that intracerebroventricular administration of NMU to 24-h fasted rats resulted in a decrease in subsequent food intake and body weight gain. NMU administration activated neurons in several brain regions implicated in the regulation of feeding behavior. Activated cells included catecholaminergic neurons of the arcuate nucleus and brain stem. Distribution studies revealed NMU expression in the caudal brain stem (nucleus of the solitary tract and inferior olive) and pituitary, with significant levels in the pars tuberalis. This contradicts earlier published observations. In obese (fa/fa) Zucker rats, decreases in NMU expression were detected in the nucleus of the solitary tract, pars tuberalis, and pars distalis, whereas in the fasted rat, a decrease in NMU transcript was detected in the pars distalis. These results confirm the effects of NMU on feeding and suggest additional roles for NMU in neuroendocrine function. |
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Authors:
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Tina R Ivanov; Catherine B Lawrence; Peter J Stanley; Simon M Luckman |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrinology Volume: 143 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-19 Completed Date: 2002-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 3813-21 Citation Subset: AIM; IM |
Affiliation:
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School of Biological Sciences, University of Manchester, United Kingdom M13 9PT. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects Body Weight / drug effects Brain / metabolism Eating / drug effects Energy Metabolism / drug effects* Homeostasis / drug effects* Injections, Intraventricular Male Neuropeptides / administration & dosage, genetics, pharmacology* Obesity / metabolism Pituitary Gland / drug effects*, physiology* Proto-Oncogene Proteins c-fos / metabolism RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Rats, Zucker Thinness Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 0/Proto-Oncogene Proteins c-fos; 0/RNA, Messenger; 117505-80-3/neuromedin U |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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