Document Detail

Evaluation of neuromedin U actions in energy homeostasis and pituitary function.
MedLine Citation:
PMID:  12239092     Owner:  NLM     Status:  MEDLINE    
The brain-gut peptide neuromedin U (NMU) has been identified recently as a physiological regulator of food intake. To further investigate the central role of NMU in energy homeostasis, we examined the distribution of NMU transcript and the effect of intracerebroventricular administration on several physiological parameters and on the pattern of c-Fos activation. Here we report that intracerebroventricular administration of NMU to 24-h fasted rats resulted in a decrease in subsequent food intake and body weight gain. NMU administration activated neurons in several brain regions implicated in the regulation of feeding behavior. Activated cells included catecholaminergic neurons of the arcuate nucleus and brain stem. Distribution studies revealed NMU expression in the caudal brain stem (nucleus of the solitary tract and inferior olive) and pituitary, with significant levels in the pars tuberalis. This contradicts earlier published observations. In obese (fa/fa) Zucker rats, decreases in NMU expression were detected in the nucleus of the solitary tract, pars tuberalis, and pars distalis, whereas in the fasted rat, a decrease in NMU transcript was detected in the pars distalis. These results confirm the effects of NMU on feeding and suggest additional roles for NMU in neuroendocrine function.
Tina R Ivanov; Catherine B Lawrence; Peter J Stanley; Simon M Luckman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinology     Volume:  143     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-19     Completed Date:  2002-10-21     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3813-21     Citation Subset:  AIM; IM    
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MeSH Terms
Body Temperature / drug effects
Body Weight / drug effects
Brain / metabolism
Eating / drug effects
Energy Metabolism / drug effects*
Homeostasis / drug effects*
Injections, Intraventricular
Neuropeptides / administration & dosage,  genetics,  pharmacology*
Obesity / metabolism
Pituitary Gland / drug effects*,  physiology*
Proto-Oncogene Proteins c-fos / metabolism
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Rats, Zucker
Tissue Distribution
Grant Support
NEU15392//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Neuropeptides; 0/Proto-Oncogene Proteins c-fos; 0/RNA, Messenger; 117505-80-3/neuromedin U

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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