Document Detail


Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 2: Effects of inhaled HDS on control and heaves horses.
MedLine Citation:
PMID:  12117104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate inhaled hay dust suspensions (HDS) as a tool for the diagnosis and investigation of heaves, the pulmonary inflammatory and functional consequences of inhalation challenge with 3 different HDS were determined in 6 control and 7 asymptomatic heaves horses. Heaves horses given HDS challenge developed the characteristic features of heaves, including airway neutrophilia, obstructive airway dysfunction and mucus hypersecretion. While HDS challenge induced a mild airway neutrophilia in controls, the no-response threshold for controls was greater than that of heaves horses, and there was no overlap in BALF neutrophil ratio of controls and heaves horses. Furthermore, HDS challenge did not induce airway dysfunction or mucus hypersecretion in controls. Therefore, HDS challenges enabled differentiation of control and heaves horses. Interestingly, in both groups, the airway neutrophilia was a dose-dependent response rather than an 'all or nothing' response. This study suggests that HDS challenges are of value in the diagnosis and investigation of heaves.
Authors:
R S Pirie; D D S Collie; P M Dixon; B C McGorum
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Equine veterinary journal     Volume:  34     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-15     Completed Date:  2002-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  IM    
Affiliation:
Wellcome Trust Centre for Research in Comparative Respiratory Medicine, Easter Bush Veterinary Centre, Roslin, Midlothian, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bronchoalveolar Lavage Fluid / cytology
Case-Control Studies
Diagnosis, Differential
Dose-Response Relationship, Immunologic
Dust / adverse effects*,  analysis
Female
Horse Diseases / diagnosis*
Horses
Housing, Animal
Inhalation Exposure
Leukocyte Count / veterinary
Male
Nebulizers and Vaporizers / veterinary*
Neutrophils / cytology
Poaceae / adverse effects
Pulmonary Disease, Chronic Obstructive / diagnosis,  veterinary*
Reproducibility of Results
Respiratory Function Tests / methods,  veterinary*
Suspensions
Time Factors
Chemical
Reg. No./Substance:
0/Dust; 0/Suspensions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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