Document Detail

Evaluation of natural change of skin function in split-thickness skin grafts by noninvasive bioengineering methods.
MedLine Citation:
PMID:  17083588     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Autologous split-thickness skin grafts (STSGs) are considered the mainstay for the treatment of large full-thickness wounds. There have been few studies reporting the natural change of the skin function in STSGs after procedure, however. OBJECTIVE: The objective was to evaluate the natural change of the skin function in STSG using noninvasive bioengineering methods. METHODS: Eighteen patients were eligible for the study. The skin functions of the graft and the control site were evaluated by an evaporimeter, corneometer, mexameter, and cutometer at Postoperation Days 0.5, 1, 2, 3, 6, 9, and 12 months. RESULTS: Transepidermal water loss (TEWL) of the graft was maintained around that of the normal skin. The values of the skin hydration testing generally decreased during the follow-up period. Erythema was highly maintained for the whole period. For the pigmentation, the ratio tended to increase after 6 months. The skin pliability of the graft was abruptly decreased at 0.5 month, and it recovered from 3 to 12 months. The value did not reach that of the normal skin, however. CONCLUSION: Our results showed that the STSGs had changed within the frame of the skin function, including the TEWL, epidermal hydration, color, and pliability, throughout 1 year after surgery. The authors have indicated no significant interest with commercial supporters.
You Jeong Kim; Mi-Yeon Kim; Paik-Kwon Lee; Hyung Ok Kim; Young Min Park
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  32     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2006-12-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1358-63     Citation Subset:  IM    
Department of Dermatology, Kangnam St Mar'y Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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MeSH Terms
Biomedical Engineering
Graft Survival
Middle Aged
Skin / injuries*,  surgery*
Skin Physiological Phenomena
Skin Transplantation / methods*
Treatment Outcome
Water Loss, Insensible

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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