| Evaluation of myocardial viability with iodine-123-BMIPP in a canine model. | |
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MedLine Citation:
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PMID: 8708784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The tracer 123I-BMIPP was examined for its ability to reflect myocardial lipid metabolism. Studies in mice indicate that myocardial BMIPP uptake correlates with ATP content. Details, however, of myocardial accumulation in the ischemic period with either infarct or ischemia are not well documented. METHODS: Sixteen adult mongrel dogs were investigated. The occluded left anterior descending artery (LAD) alone was reperfused to make the ischemic area, and the first diagonal branch of the LAD was kept occluded to make the infarct area. Regional wall motion was evaluated by echocardiography in the short-axial view from the epicardium. Tissue blood flow was calculated using nonradioactive colored microspheres. Changes in blood glucose levels, lipid levels and lactate extraction were examined in blood collected from the aorta and great cardiac vein (GCV). The ATP concentration and BMIPP count were determined by high-performance liquid chromatography and gamma-counter, respectively. RESULTS: Two hours after reperfusion, blood flow decreased to 20% +/- 5% in the infarct area and 64% +/- 9% in the ischemic area (p < 0.05), despite comparable wall-motion reduction (32% +/- 5% and 42% +/- 12% in the infarct and ischemic areas, respectively). BMIPP content and ATP concentration showed parallel reduction: 40% +/- 7% and 75% +/- 4% (p < 0.05) of BMIPP and 32% +/- 9% and 69% +/- 7% (p < 0.05) of ATP in the infarct and ischemic areas, respectively. The nonesterified fatty acid extraction, defined as flow x ([artery] - [GCV]), decreased to 87% +/- 5.6% during occlusion and 75% +/- 20.1% 2 hr after reperfusion, as compared with the control value. CONCLUSION: BMIPP uptake correlated well with lipid metabolism and tissue ATP levels and may prove useful in differentiating myocardial infarction from ischemia in the acute phase of ischemic episodes. |
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Authors:
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R Nohara; K Okuda; M Ogino; R Hosokawa; N Tamaki; J Konishi; Y Fujibayashi; Y Yonekura; M Fujita; S Sasayama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 37 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1996-09-11 Completed Date: 1996-09-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1403-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Faculty of Pharmaceutical Sciences, Kyoto University Hospital, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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analysis Animals Chromatography, High Pressure Liquid Coronary Circulation / physiology Dogs Fatty Acids / diagnostic use* Iodine Radioisotopes / diagnostic use* Iodobenzenes / diagnostic use* Microspheres Myocardial Contraction / physiology Myocardial Ischemia / radionuclide imaging* Myocardial Reperfusion Injury / radionuclide imaging* Myocardium / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Iodine Radioisotopes; 0/Iodobenzenes; 116754-87-1/iodofiltic acid; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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