Document Detail


Evaluation of myocardial viability during simple cold storage with the use of electrical properties in broad frequencies.
MedLine Citation:
PMID:  8913918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The purpose of this study ws to determine whether myocardial viability during simple cold storage can be monitored from alteration of electrical properties of the preserved heart. METHODS: Twelve anesthetized dogs underwent rapid cardiac extirpation and were preserved in simple cold storage ( 4 degree C). They were divided into two groups according to preservation solutions. Groups S and U were preserved in saline and University of Wisconsin Solutions, respectively. The loss-tangent (Tan delta) in dielectric spectroscopy was analyzed on serial measurements of electrical properties of the preserved heart with an electrical impedance meter. Myocardial specimens were taken for myocardial adenosine triphosphate measurement with high-performance liquid chromatography and myocardial water content. We investigated the correlations among myocardial adenosine triphosphate, myocardial water content, and Tan delta. RESULTS: The maximum value of Tan delta corresponds to a frequency fT which ranged from 5 to 10 kHz in both groups and maximum Tan delta gradually decreased during preservation in both groups. Myocardial adenosine triphosphate in group U was significantly higher than that in group S. The ratio of measured adenosine triphosphate and maximum Tan delta to the preischemic values during preservation were expressed as percentage of adenosine triphosphate and percentage of maximum Tan delta. There was close correlation between myocardial percentage of adenosine triphosphate and percentage of maximum Tan delta during preservation in both groups. Myocardial water content in group S increased during preservation but did not increase in group U. There was no correlation between myocardial water content and percentage of maximum Tan delta during preservation. Tan delta function were used to characterize the electrical properties of biologic tissue and were clearly associated with ischemic histologic damage of tissues. CONCLUSIONS: Therefore measurement of electrical properties in broad frequencies of the preserved heart may be feasible as a monitor of graft viability in a minimally invasive method.
Authors:
M Ishikawa; H Hirose; E Sasaki; M Bando; Y Mori; S Murakawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  15     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-18     Completed Date:  1997-02-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1005-11     Citation Subset:  IM    
Affiliation:
First Department of Surgery, Gifu University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenosine
Adenosine Triphosphate / metabolism
Allopurinol
Animals
Body Water / metabolism
Cardioplegic Solutions
Cold Temperature
Dogs
Electric Conductivity
Glutathione
Heart* / physiology
Heart Conduction System / physiology
Heart Transplantation / physiology
Insulin
Myocardium / metabolism
Organ Preservation*
Organ Preservation Solutions*
Raffinose
Tissue Survival
Chemical
Reg. No./Substance:
0/Cardioplegic Solutions; 0/Organ Preservation Solutions; 0/University of Wisconsin-lactobionate solution; 11061-68-0/Insulin; 315-30-0/Allopurinol; 512-69-6/Raffinose; 56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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