Document Detail

Evaluation of myocardial sympathetic nerve function in patients with mitral valve prolapse using iodine-123-metaiodobenzylguanidine myocardial scintigraphy.
MedLine Citation:
PMID:  18084877     Owner:  NLM     Status:  MEDLINE    
Mitral valve prolapse (MVP) is closely related to myocardial sympathetic nerve function. This study evaluated the presence of impaired myocardial sympathetic nerve function by Iodine-123-metaiodobenzylguanidine (MIBG) scintigraphy in ten patients with MVP. For comparison, 15 healthy subjects without heart disease were investigated (control group). Single photon emission computed tomography (SPECT) and anterior planar myocardial scintigraphy were performed 15 min (initial images) and 3 hours (delayed images) after injection of MIBG (111 MBq). The location and degrees of reduced tracer uptake were evaluated. Myocardial MIBG uptake was quantified by uptake ratio of the heart (H) to upper mediastinum (M) on the anterior planar images (H/M). Percentage washout of MIBG in nine sectors of all oblique slices along the short-axis was calculated. The washout rates were higher at the inferoposterior and septal segments in patients with anterior leaflet prolapse, and at inferoposterior and lateral segments in patients with posterior leaflet prolapse. The bull's eye map showed increased washout rate in the apical and posteroseptal basal segments. There was no significant difference in the H/M ratio between MVP patients and the control group. These results indicate that MIBG can be used to evaluate localized myocardial sympathetic nerve function in MVP.
F Kishi; M Nomura; E Uemura; N Kageyama; S Kujime; M Kaji; Y Noda; N Kondo; T Kawaguchi; Y Ozaki; K Koshiba; K Yamaguchi; Y Nakaya; S Ito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicine     Volume:  35     ISSN:  0025-7850     ISO Abbreviation:  J Med     Publication Date:  2004  
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505566     Medline TA:  J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  187-99     Citation Subset:  IM    
Department of Digestive and Cardiovascular Medicine, University of Tokushima Graduate School, Tokushima 770-8053, Japan.
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MeSH Terms
3-Iodobenzylguanidine / administration & dosage,  diagnostic use*
Heart / innervation*,  radionuclide imaging*
Middle Aged
Mitral Valve Prolapse / physiopathology,  radionuclide imaging*
Radiopharmaceuticals / administration & dosage,  diagnostic use*
Sympathetic Nervous System / physiopathology*,  radionuclide imaging
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Radiopharmaceuticals; 77679-27-7/3-Iodobenzylguanidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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