Document Detail

Evaluation of myocardial CT perfusion in patients presenting with acute chest pain to the emergency department: comparison with SPECT-myocardial perfusion imaging.
MedLine Citation:
PMID:  22895647     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether evaluation of resting myocardial CT perfusion (CTP) from coronary CT angiography (CTA) datasets in patients presenting with chest pain (CP) to the emergency department (ED), might have added value to coronary CTA.
DESIGN, SETTING: 76 Patients (age 54.9 y±13; 32 (42%) women) presenting with CP to the ED underwent coronary 64-slice CTA. Myocardial perfusion defects were evaluated for CTP (American Heart Association 17-segment model) and compared with rest sestamibi single-photon emission CT myocardial perfusion imaging (SPECT-MPI). CTA was assessed for >50% stenosis per vessel.
RESULTS: CTP demonstrated a sensitivity of 92% and 89%, specificity of 95% and 99%, positive predictive value (PPV) of 80% and 82% and negative predictive value (NPV) of 98% and 99% for each patient and for each segment, respectively. CTA showed an accuracy of 92%, sensitivity of 70.4%, specificity of 95.5%, PPV 67.8%, and NPV of 95% compared with SPECT-MPI. When CTP findings were added to CTA the PPV improved from 67% to 90.1%.
CONCLUSIONS: In patients presenting to the ED with CP, the evaluation of rest myocardial CTP demonstrates high diagnostic performance as compared with SPECT-MPI. Addition of CTP to CTA improves the accuracy of CTA, primarily by reducing rates of false-positive CTA.
Gudrun Maria Feuchtner; Fabian Plank; Constantino Pena; Juan Battle; James Min; Jonathon Leipsic; Troy Labounty; Warren Janowitz; Barry Katzen; Jack Ziffer; Ricardo C Cury
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-15
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  98     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-24     Completed Date:  2012-12-03     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1510-7     Citation Subset:  AIM; IM    
Baptist Cardiac and Vascular Institute, Baptist Hospital Miami, Miami, FL, USA.
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MeSH Terms
Chest Pain / etiology*
Coronary Angiography / methods*
Coronary Disease / complications*,  diagnosis*
Emergency Service, Hospital
Middle Aged
Myocardial Perfusion Imaging*
Reproducibility of Results
Tomography, Emission-Computed, Single-Photon*
Tomography, X-Ray Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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