| Evaluation of the mydriatic effect of intracameral lidocaine hydrochloride injection in eyes of clinically normal dogs. | |
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MedLine Citation:
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PMID: 19951124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE-To evaluate the mydriatic effect of intracameral injection of preservative-free 1% and 2% lidocaine hydrochloride solutions and determine the onset and duration of mydriasis according to the concentration and volume of lidocaine administered in healthy dogs. ANIMALS-5 healthy adult Beagles weighing 7 to 10 kg, with no apparent ocular disease. PROCEDURES-A double-blind randomized 9-session crossover trial was designed. Both eyes were assigned to 9 treatments with a minimum 7-day washout period between treatments: 0.1, 0.2, and 0.3 mL of 2% lidocaine solution; 0.1, 0.2, and 0.3 mL of 1% lidocaine solution; and 0.1, 0.2, and 0.3 mL of balanced salt solution. Dogs were anesthetized, and the allocated treatment was injected intracamerally after aspiration of the same volume of aqueous humor from the anterior chamber of each eye. Two perpendicular pupil diameters were measured. Intraocular pressure, heart rate, respiratory rate, ECG readings, and end-tidal partial pressure of CO(2) were monitored. RESULTS-Intracameral injection of 1% or 2% lidocaine solutions in volumes of 0.1 to 0.3 mL induced a significant degree of mydriasis, and the effect was maintained for 74 to 142 minutes. Lidocaine injection had no significant effect on intraocular pressure, heart rate, respiratory rate, ECG readings, or end-tidal partial pressure of CO(2). CONCLUSIONS AND CLINICAL RELEVANCE-Intracameral lidocaine injection in healthy dogs induced mydriasis, the timing of which was affected by concentration and volume of lidocaine. This technique could serve as an alternative to topically administered mydriatics for intraocular surgery in dogs. |
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Authors:
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Shin-Ae Park; Na-Ra Kim; Young-Woo Park; Man-Bok Jeong; Won-Tae Kim; Se-Eun Kim; Tae-Hyun Kim; Kang-Moon Seo |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 70 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-02 Completed Date: 2010-02-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: United States |
Other Details:
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Languages: eng Pagination: 1521-5 Citation Subset: IM |
Affiliation:
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Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, and BK21 Program for Veterinary Science, Seoul National University, San 56-1, Sillim 9-dong, Gwanakgu, Seoul 151-742, Republic of Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cross-Over Studies Dogs* Dose-Response Relationship, Drug Female Lidocaine / administration & dosage, pharmacology* Male Mydriasis / chemically induced* Mydriatics / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Mydriatics; 137-58-6/Lidocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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