Document Detail


Evaluation of mutagenic activity of several antimalarial extracts from Eupatorium inulaefolium.
MedLine Citation:
PMID:  11400559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eupatorium inulaefolium is used as an antimalarial agent by traditional healers of the Tumaco region (Nariño-Colombia). Several extracts of this plant have been tested by our laboratory and in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum has been confirmed. For this reason, the mutagenic effect of the methanol, dichloromethane, and hexane extracts of Eupatorium inulaefolium (number 83377 university of Antioquia herbarium) were evaluated using the Ames test. None of the extracts evaluated had mutagenic effects on TA-98 or TA-100 strains of Salmonella typhimurium.
Authors:
A Pabón; T Lopera; J Carmona; S Blair
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Publication Detail:
Type:  Evaluation Studies; In Vitro; Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  56     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-12     Completed Date:  2001-07-05     Revised Date:  2007-01-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  412-4     Citation Subset:  IM    
Affiliation:
Malaria Group, University of Antioquia, Medellín, Colombia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimalarials / toxicity*
Base Pair Mismatch / drug effects
DNA, Bacterial / drug effects,  genetics
Frameshift Mutation / drug effects
Male
Mutagenicity Tests
Mutagens / toxicity*
Plant Extracts / toxicity
Plants, Medicinal / chemistry*
Rats
Salmonella typhimurium / drug effects,  genetics
Solvents
Subcellular Fractions / drug effects,  enzymology
Chemical
Reg. No./Substance:
0/Antimalarials; 0/DNA, Bacterial; 0/Mutagens; 0/Plant Extracts; 0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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