Document Detail


Evaluation of multicentre clinical trial data using adaptations of the Mosteller-Tukey procedure.
MedLine Citation:
PMID:  8341865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two procedures, based on proposals discussed by Mosteller and Tukey, are described for obtaining a combined estimate of the difference between two treatment means and its confidence interval from multicentre clinical trial data. Both procedures provide estimates in the possible presence of heteroscedasticity. The first procedure is designated the primary analysis for efficacy assessment. It omits treatment-by-centre interaction from the error term for treatment, unless there is substantial evidence of qualitative interaction (Ciminera et al.) or other special circumstances. The second procedure is the primary analysis whenever there is substantial evidence of qualitative interaction, and can be used whenever there are other reasons to make an analysis allowing for interaction.
Authors:
J L Ciminera; J F Heyse; H H Nguyen; J W Tukey
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Statistics in medicine     Volume:  12     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-02     Completed Date:  1993-09-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1047-61     Citation Subset:  IM    
Affiliation:
Merck Research Laboratories, West Point, PA 19486.
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MeSH Terms
Descriptor/Qualifier:
Asthma / drug therapy,  epidemiology,  physiopathology
Blood Pressure / drug effects
Clinical Trials as Topic / methods*
Confidence Intervals
Data Interpretation, Statistical
Humans
Multicenter Studies as Topic / methods*
Normal Distribution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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