| Evaluation of the mucosal irritation potency of co-spray dried Amioca/poly(acrylic acid) and Amioca/Carbopol 974P mixtures. | |
| | |
MedLine Citation:
|
PMID: 12644365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this study was to evaluate the biocompatibility of different Amioca/poly(acrylic acid) and Amioca/Carbopol 974P co-spray dried mixtures with an alternative mucosal irritation test using slugs. The irritation potential of the mixtures was measured by the amount of mucus produced during a repeated 30-min contact period. Additionally, membrane damage was assessed by measuring the protein and enzyme release from the body wall of slugs after treatment. All the Amioca/poly(acrylic acid) co-spray dried mixtures (50:50 and 25:75 ratios) induced slight irritation of the mucosal tissue as was demonstrated by the significantly increased mucus production however no increased protein and enzyme release was detected. Co-spray dried Amioca/Carbopol 974P mixtures containing 40% and more Carbopol 974P demonstrated a significantly higher mucus production and release of cytosolic LDH, indicating membrane damage. The total mucus production of the slugs treated with the co-spray dried mixtures containing up to 20% Carbopol 974P was significantly higher compared to the blank slugs. However, these mixtures induced no membrane damage since no additional effect on the protein release and no enzyme release was detected. By co-spray drying up to 20% Carbopol 974P could be incorporated without showing a distinct sign of irritation. These mixtures can be considered as potentially safe bioadhesive carriers. |
| | |
Authors:
|
E Adriaens; D Ameye; M M M Dhondt; P Foreman; J P Remon |
Related Documents
:
|
9335345 - The protective effect of zinc on rosin and resin acid toxicity in human polymorphonucle... 17370275 - Biosynthesis and biodegradability of copolythioesters from 3,3'-thiodipropionic acid an... 15005225 - Abrasive effect of brushing on ormocers following acid conditioning. 9663755 - Synthesis and characterization of self-catalyzed poly(ortho ester). 6245165 - The response of the kidney of the freshwater rainbow trout to true metabolic acidosis. 21966595 - Novel conjugates of 1,3-diacylglycerol and lipoic acid: synthesis, dpph assay, and rp-l... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 88 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 2003 Mar |
Date Detail:
|
Created Date: 2003-03-19 Completed Date: 2003-10-14 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 393-9 Citation Subset: IM |
Affiliation:
|
Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acrylates
/
chemistry,
toxicity* Acrylic Resins / chemistry, toxicity* Acute Toxicity Tests / methods Animals Chemistry, Pharmaceutical Drug Evaluation, Preclinical / methods Mucous Membrane / drug effects*, physiology Mucus / drug effects, physiology Powders Reproducibility of Results Snails |
| Chemical | |
Reg. No./Substance:
|
0/Acrylates; 0/Acrylic Resins; 0/Powders; 0/carbopol 974P NF; 9003-01-4/carbopol 940 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preparation and evaluation of a melt pelletised paracetamol/stearic acid sustained release delivery ...
Next Document: Optimization of a thermally reversible W/O/W multiple emulsion for shear-induced drug release.