Document Detail

Evaluation of monoexponential extrapolation of transpulmonary thermal-dye kinetics by use of a new model-free deconvolution algorithm.
MedLine Citation:
PMID:  3282155     Owner:  NLM     Status:  MEDLINE    
This study evaluates the routine mathematic approach (monoexponential extrapolation) for analysis of transpulmonary thermal-dye dilution curves and estimates the effects of systemic-indicator recirculation by use of a deconvolution technique. Fifteen dogs anesthetized with N2O-piritramid were studied before and after induction of pulmonary edema by oleic acid. After introduction of central venous indicator (10 ml of a mixture of cold blood and indocyanine green dye), dilution data were recorded from the pulmonary artery and the ascending aorta. The conclusions were: (1) monoexponential extrapolation yields reasonably good estimates of the mean transit times of dye; (2) mean transit times of heat are usually overestimated by monoexponential extrapolation; (3) extravascular lung thermal volume assessed by monoexponential extrapolation is overestimated by 2.03 ml/kg of body mass under baseline conditions; and (4) the prepulmonary volume of distribution of heat exceeds that of dye by 1.4 ml/kg of body mass, thus increasing the overestimation of pulmonary extravascular heat-accessible space by the conventional technique.
J C Böck; P Deuflhard; A Hoeft; H Korb; J Steinmann; H G Wolpers; G Hellige
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical instrumentation     Volume:  22     ISSN:  0090-6689     ISO Abbreviation:  Med Instrum     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-05-26     Completed Date:  1988-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361136     Medline TA:  Med Instrum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20-8     Citation Subset:  IM    
Zentrum Physiologie und Pathophysiologie, Universität Göttingen, Federal Republic of Germany.
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MeSH Terms
Cardiac Output
Dye Dilution Technique
Extracellular Space / metabolism*
Indocyanine Green / diagnostic use*
Lung / metabolism*
Models, Biological
Oleic Acid
Oleic Acids
Pulmonary Edema / chemically induced,  physiopathology
Reg. No./Substance:
0/Oleic Acids; 112-80-1/Oleic Acid; 3599-32-4/Indocyanine Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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