| Evaluation of monoexponential extrapolation of transpulmonary thermal-dye kinetics by use of a new model-free deconvolution algorithm. | |
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MedLine Citation:
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PMID: 3282155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluates the routine mathematic approach (monoexponential extrapolation) for analysis of transpulmonary thermal-dye dilution curves and estimates the effects of systemic-indicator recirculation by use of a deconvolution technique. Fifteen dogs anesthetized with N2O-piritramid were studied before and after induction of pulmonary edema by oleic acid. After introduction of central venous indicator (10 ml of a mixture of cold blood and indocyanine green dye), dilution data were recorded from the pulmonary artery and the ascending aorta. The conclusions were: (1) monoexponential extrapolation yields reasonably good estimates of the mean transit times of dye; (2) mean transit times of heat are usually overestimated by monoexponential extrapolation; (3) extravascular lung thermal volume assessed by monoexponential extrapolation is overestimated by 2.03 ml/kg of body mass under baseline conditions; and (4) the prepulmonary volume of distribution of heat exceeds that of dye by 1.4 ml/kg of body mass, thus increasing the overestimation of pulmonary extravascular heat-accessible space by the conventional technique. |
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Authors:
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J C Böck; P Deuflhard; A Hoeft; H Korb; J Steinmann; H G Wolpers; G Hellige |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical instrumentation Volume: 22 ISSN: 0090-6689 ISO Abbreviation: Med Instrum Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-05-26 Completed Date: 1988-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361136 Medline TA: Med Instrum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 20-8 Citation Subset: IM |
Affiliation:
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Zentrum Physiologie und Pathophysiologie, Universität Göttingen, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Animals Cardiac Output Dogs Dye Dilution Technique Extracellular Space / metabolism* Female Indocyanine Green / diagnostic use* Lung / metabolism* Male Models, Biological Oleic Acid Oleic Acids Pulmonary Edema / chemically induced, physiopathology Thermodilution |
| Chemical | |
Reg. No./Substance:
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0/Oleic Acids; 112-80-1/Oleic Acid; 3599-32-4/Indocyanine Green |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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