| Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using yeast models of OXPHOS deficiencies. | |
| | |
MedLine Citation:
|
PMID: 19806592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The oxidative phosphorylation (OXPHOS) system consists of five multimeric complexes embedded in the mitochondrial inner membrane. They work in concert to drive the aerobic synthesis of ATP. Mitochondrial and nuclear DNA mutations affecting the accumulation and function of these enzymes are the most common cause of mitochondrial diseases and have also been associated with neurodegeneration and aging. Several approaches for the assessment of the OXPHOS system enzymes have been developed. Based on the methods described elsewhere, this unit describes the creation and study of yeast models of mitochondrial OXPHOS deficiencies. |
| | |
Authors:
|
Flavia Fontanesi; Francisca Diaz; Antoni Barrientos |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] Volume: Chapter 19 ISSN: 1934-8258 ISO Abbreviation: Curr Protoc Hum Genet Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-10-06 Completed Date: 2009-10-14 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 101287858 Medline TA: Curr Protoc Hum Genet Country: United States |
Other Details:
|
Languages: eng Pagination: Unit19.5 Citation Subset: IM |
Affiliation:
|
University of Miami Miller School of Medicine, Miami, Florida, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Humans Mitochondria / chemistry*, metabolism Models, Biological Mutation Oxidative Phosphorylation* Saccharomyces cerevisiae / chemistry*, genetics, metabolism Saccharomyces cerevisiae Proteins / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
R01 GM071775-01A2/GM/NIGMS NIH HHS; R01 GM071775A/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Saccharomyces cerevisiae Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using blue na...
Next Document: Molecular analysis of Fragile X syndrome.