Document Detail

Evaluation of minoxidil.
MedLine Citation:
PMID:  6994495     Owner:  NLM     Status:  MEDLINE    
The chemistry, pharmacokinetics, mechanism of action, clinical studies, adverse effects, toxicology, indications, contraindications, drug interactions, and dosing of minoxidil, a recently approved antihypertensive agent, are reviewed. Minoxidil is an orally effective vasodilator that selectively relaxes peripheral arteriolar smooth muscle, Reflex tachycardia, renin stimulation, and sodium retention occur when minoxidil is used and so it requires the concomitant use of a diuretic and a sympathoplegic agent, usually a beta blocker. Hirsutism and pericardial effusions are additional adverse effects. Minoxidil is indicated in the management of severe hypertension in patients who do not respond to standard antihypertensive agents. In controlled and unctrolled studies, minoxidil was effective in patients with hypertension secondary to renal or renovascular disease and in patients with essential hypertension. Minoxidil is a potent antihypertensive agent with adverse effects that limit its use to patients resistant or intolerant to other drugs.
D D Miller; D W Love
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Publication Detail:
Type:  Clinical Trial; Journal Article; Review    
Journal Detail:
Title:  American journal of hospital pharmacy     Volume:  37     ISSN:  0002-9289     ISO Abbreviation:  Am J Hosp Pharm     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-09-28     Completed Date:  1980-09-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370474     Medline TA:  Am J Hosp Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  808-14     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Drug Administration Schedule
Hypertension / drug therapy
Minoxidil / adverse effects,  metabolism,  pharmacology,  therapeutic use*
Pyrimidines / therapeutic use*
Reg. No./Substance:
0/Pyrimidines; 38304-91-5/Minoxidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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