Document Detail


Evaluation of minimally invasive excisional brain biopsy and intracranial brachytherapy catheter placement in dogs.
MedLine Citation:
PMID:  21194343     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective-To evaluate a technique for minimally invasive excisional brain biopsy and intracranial brachytherapy catheter placement in dogs. Animals-5 healthy adult female dogs. Procedures-Computed tomographic guidance was used to plan a biopsy trajectory to a selected area of brain with reference to a localizer grid. The procedure was performed through a 1-cm skin incision and 6-mm burr hole by use of a 9-gauge biopsy device. Five cylindrical samples (3 to 4 mm in diameter and 7 to 12 mm in length) were removed over 5 cycles of the vacuum-assisted tissue excision system, leaving approximately a 2-cm(3) resection cavity. A balloon-tipped intracranial brachytherapy catheter was placed through the burr hole into the resection cavity, expanded with saline (0.9% NaCl) solution, and explanted 7 days later. Results-4 of 5 dogs survived the procedure. The fifth died because of iatrogenic brain damage. Neurologic deficits were unilateral and focal. Twenty-four hours after surgery, all surviving dogs were ambulatory, 2 dogs exhibited ipsiversive circling, 4 had contralateral proprioceptive deficits, 3 had contralateral menace response deficits, 2 had a reduced contralateral response to noxious nasal stimulation, and 1 had dull mentation with intermittent horizontal nystagmus and ventrolateral strabismus. Neurologic status improved throughout the study period. Histologic quality of biopsy specimens was excellent. Conclusions and Clinical Relevance-This technique enabled histologic diagnosis from high-quality biopsy specimens obtained through a minimally invasive technique and has potential applications for multimodal treatment of deep brain tumors in dogs.
Authors:
Rebecca A Packer; Lynetta J Freeman; Margaret A Miller; Amy E Fauber; Wallace B Morrison
Related Documents :
18057433 - Bleeding pseudoaneurysms complicating upper abdominal surgery.
17430373 - Perioperative management of von willebrand disease in dermatologic surgery.
11274313 - Recurrent brain hemorrhage is more frequent than ischemic stroke after intracranial hem...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  72     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-21     Citation Subset:  IM    
Affiliation:
Departments of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907., Basic Medical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of an acute focal epidural mass model to characterize the intracranial pressure-volume re...
Next Document:  Pharmacokinetics and bioavailability of cefquinome in healthy ducks.