Document Detail

Evaluation of microvessel density by computerised image analysis in human renal cell carcinoma. Correlation to pT category, nuclear grade, proliferative activity and occurrence of metastasis.
MedLine Citation:
PMID:  9619739     Owner:  NLM     Status:  MEDLINE    
A high microvessel density is suspected to favour tumour progression and the occurrence of metastasis. To elucidate the significance of abundant vessels for the behaviour of human renal carcinomas, the microvessel density of 110 renal cell carcinomas was correlated to pT category, nuclear grade, proliferative activity, occurrence of metastasis and relapse-free survival interval. The microvessels were quantified using CD31 immunostaining of endothelial cells and computer-aided image analysis. The rules for reproducible microvessel counting, as defined by Weidner, were strictly observed. A statistically significant relationship between the microvessel density and nuclear grade, proliferative activity, occurrence of metastasis and relapse-free survival was found; only for tumour size could no such relation be seen. Perplexingly, there is a diminution of microvessel density in association with increasing nuclear grade, proliferative activity, relapse-free survival interval and frequency of metastasis. This finding is contradictory to the hypothesis that an increasing microvessel density indicates a worsening prognosis.
C Herbst; H Kosmehl; K J Stiller; A Berndt; M Eiselt; J Schubert; D Katenkamp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  124     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  1998  
Date Detail:
Created Date:  1998-06-19     Completed Date:  1998-06-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Institute of Pathology, Friedrich Schiller University, Jena, Germany.
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MeSH Terms
Antigens, CD31 / immunology
Carcinoma, Renal Cell / blood supply*,  pathology*
Cell Division / physiology
Cross Reactions
Kidney Neoplasms / blood supply*,  pathology*
Neoplasm Metastasis
Reg. No./Substance:
0/Antibodies; 0/Antigens, CD31

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