Document Detail


Evaluation of microvessel density by computerised image analysis in human renal cell carcinoma. Correlation to pT category, nuclear grade, proliferative activity and occurrence of metastasis.
MedLine Citation:
PMID:  9619739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A high microvessel density is suspected to favour tumour progression and the occurrence of metastasis. To elucidate the significance of abundant vessels for the behaviour of human renal carcinomas, the microvessel density of 110 renal cell carcinomas was correlated to pT category, nuclear grade, proliferative activity, occurrence of metastasis and relapse-free survival interval. The microvessels were quantified using CD31 immunostaining of endothelial cells and computer-aided image analysis. The rules for reproducible microvessel counting, as defined by Weidner, were strictly observed. A statistically significant relationship between the microvessel density and nuclear grade, proliferative activity, occurrence of metastasis and relapse-free survival was found; only for tumour size could no such relation be seen. Perplexingly, there is a diminution of microvessel density in association with increasing nuclear grade, proliferative activity, relapse-free survival interval and frequency of metastasis. This finding is contradictory to the hypothesis that an increasing microvessel density indicates a worsening prognosis.
Authors:
C Herbst; H Kosmehl; K J Stiller; A Berndt; M Eiselt; J Schubert; D Katenkamp
Related Documents :
17063319 - Long-term domain-specific improvement following poor grade aneurysmal subarachnoid hemo...
6322629 - Labeling indices of human lung cancer. correlation with histologic type and survival.
17452919 - Curettage of biopsy-diagnosed grade 1 periacetabular chondrosarcoma.
8972469 - Proliferative activity, angiogenesis, and necrosis in peripheral nerve sheath tumors: a...
9486579 - Toward the development of a universal grading system for ovarian epithelial carcinoma: ...
15087669 - Grading ovarian serous carcinoma using a two-tier system.
16153209 - Assessing the size and stage of testicular germ cell tumours: 1984-2003.
18425339 - Prophylactic pelvic irradiation as part of primary therapy in uterine sarcomas.
16871949 - Cisplatin, gemcitabine and paclitaxel triplet chemotherapy in 50 patients with advanced...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  124     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  1998  
Date Detail:
Created Date:  1998-06-19     Completed Date:  1998-06-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Affiliation:
Institute of Pathology, Friedrich Schiller University, Jena, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antibodies
Antigens, CD31 / immunology
Carcinoma, Renal Cell / blood supply*,  pathology*
Cell Division / physiology
Cross Reactions
Humans
Immunohistochemistry
Kidney Neoplasms / blood supply*,  pathology*
Neoplasm Metastasis
Prognosis
Chemical
Reg. No./Substance:
0/Antibodies; 0/Antigens, CD31

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dietary cancer risk conditional cancerogens in produce of livestock fed on species of spurge (Euphor...
Next Document:  Additive effect of concomitant multiple low-dose doxorubicin and thoracic irradiation on ex vivo car...