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Evaluation of the microvascularization of pathologic parathyroid glands in patients with primary hyperparathyroidism using conventional ultrasound and contrast-enhanced ultrasound.
MedLine Citation:
PMID:  21876238     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Purpose: The objective was to characterize the microcirculation of parathyroid adenomas using contrast-enhanced ultrasound (CEUS) and to evaluate if it can be used for diagnosis and localization of pathologic glands. Patients and methods: Thirty patients with primary hyperparathyroidism scheduled for parathyroidectomy were enrolled. Preoperatively, all patients underwent B-Scan sonography, Colour coded Doppler Sonography (CCDS), Power Doppler (PD) and CEUS. The diagnostic confidence concerning B-Scan, CCDS, PD and CEUS was classified into six grades (0: no adenoma; 5: adenoma). Results: Using CEUS, all adenomatous glands showed a typical dynamic microvascularization. B-Scan showed a mean grade of 2.18, CCDS 2.29, PD 2.33, CEUS 4.29 (6-9 MHz transducer) and 3.52 (6-15 MHz). The differences between CEUS and conventional sonography were all statistically significant (p < 0.05). CEUS noted a sensitivity of 98.4% and specificity of 98.4% for the detection of adenomatous glands. Conclusion: CEUS facilitates the detection and diagnosis of pathologic parathyroid glands due to their typical microvascularization.
Authors:
W Uller; E M Jung; M Hornung; C Ross; W Jung; H J Schlitt; C Stroszczynski; A Agha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  48     ISSN:  1875-8622     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-08-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  95-103     Citation Subset:  IM    
Affiliation:
Department of Radiology, University Medical Center of Regensburg, Regensburg, Germany.
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