| Evaluation of the microcirculatory effects of Venoruton in patients with chronic venous hypertension by laserdoppler flowmetry, transcutaneous PO2 and PCO2 measurements, leg volumetry and ambulatory venous pressure measurements. | |
| | |
MedLine Citation:
|
PMID: 2662674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The evaluation of the effects of venoactive drugs and particularly of Venoruton may be performed using microcirculatory parameters. Laserdoppler flowmetry may be used in association with PO2/PCO2 measurements. In this study we combined the microcirculatory evaluation with foot and leg volumetry to evaluate the effects of Venoruton in 15 patients with deep (popliteal vein) incompetence and venous hypertension, treated for 6 weeks. A control group of 20 patients was also evaluated. All these subjects were studied and selected according to ambulatory venous pressure measurements (AVP) and duplex scanning. Measurements were made at the internal perimalleolar region in constant temperature condition (23 degrees C). No variations of AVP or duplex scanning findings were observed after 6 weeks in both treated and untreated patients. Laserdoppler flowmetry showed a significant decrease of the resting flow (which was increased in all patients at the beginning of the study). An increased efficacy of the venoarteriolar response was also recorded together with an increased response of skin flow after increase of temperature in the perimalleolar region in patients treated with Venoruton. This was also associated with an increase of skin PO2 and with a decreased PCO2. In the control group no significant variations of these parameters were observed. Leg volume was also significantly decreased in the patients treated with Venoruton while no changes were observed in controls. In conclusion this study showed the efficacy of Venoruton in improving parameters altered in venous hypertension and the possibility of application of this microcirculatory model to study venoactive drugs used for treating venous hypertension. |
| | |
Authors:
|
G Belcaro; A Rulo; C Candiani |
Related Documents
:
|
18497464 - Additional small amounts of diuretics improve blood pressure control at low cost withou... 8872824 - Acceptance and side effects of ambulatory blood pressure monitoring: evaluation of a ne... 9707624 - A genetic defect resulting in mild low-renin hypertension. 15557954 - Ileal varices and portal hypertensive ileopathy in patients with cirrhosis and portal h... 17709024 - Korean experience with double balloon endoscopy: korean association for the study of in... 21141014 - Pattern and determinants of ocular complications in leprosy patients in eastern nepal. |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: VASA. Zeitschrift für Gefässkrankheiten Volume: 18 ISSN: 0301-1526 ISO Abbreviation: VASA Publication Date: 1989 |
Date Detail:
|
Created Date: 1989-08-10 Completed Date: 1989-08-10 Revised Date: 2012-10-19 |
Medline Journal Info:
|
Nlm Unique ID: 0317051 Medline TA: Vasa Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 146-51 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anticoagulants
/
therapeutic use* Blood Gas Monitoring, Transcutaneous* Clinical Trials as Topic Female Humans Hydroxyethylrutoside / analogs & derivatives*, therapeutic use Lasers / diagnostic use* Leg / blood supply Lymphedema / drug therapy Male Microcirculation / drug effects Middle Aged Postphlebitic Syndrome / blood, drug therapy* Random Allocation Rutin / analogs & derivatives* Venous Insufficiency / blood, drug therapy* Venous Pressure / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Anticoagulants; 0/Hydroxyethylrutoside; 153-18-4/Rutin; 7085-55-4/troxerutin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Skin flow and swelling in post-phlebitic limbs.
Next Document: Delayed arterial thrombosis following an apparently trivial low-voltage electric injury.