Document Detail

Evaluation of methylene blue, thiamine, and/or albumin in the prevention of ifosfamide-related neurotoxicity.
MedLine Citation:
PMID:  20861178     Owner:  NLM     Status:  In-Data-Review    
RESULTS: A total of 166 cycles were included. For the primary endpoint, more cycles in the prophylaxis group had patients with symptoms of IIE (21.1% in the prophylaxis group vs. 8.4% in the nonprophylaxis group); p = 0.026. The average number of risk factors per cycle was the same in each group; however, the type of risk factors differed.
CONCLUSIONS: Prophylaxis was not associated with a reduced incidence of IIE, and it does not appear to delay time to onset of symptoms at our institution.
RESULT: of this study provide no support for using methylene blue, thiamine, and/or albumin as routine prophylaxis when administering ifosfamide to adults with sarcoma.
Ashley Richards; Helen Marshall; Amy McQuary
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Publication Detail:
Type:  Journal Article     Date:  2010-09-22
Journal Detail:
Title:  Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners     Volume:  17     ISSN:  1477-092X     ISO Abbreviation:  J Oncol Pharm Pract     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9511372     Medline TA:  J Oncol Pharm Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  372-80     Citation Subset:  IM    
University of Washington Medical Center/Seattle Cancer Care Alliance, Seattle, WA, USA; Pharmacy Department, Shands Healthcare at the University of Florida, Gainesville, FL 32610, USA.
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