Document Detail

Evaluation of the metabolic compensation after treadmill test in patients with peripheral occlusive arterial disease.
MedLine Citation:
PMID:  1536473     Owner:  NLM     Status:  MEDLINE    
Patterns of release of lactate, hypoxanthine, and arginine into the bloodstream after a standardized treadmill test (twelve minutes, 1.6-2.8 mph, inclination 0,5,10,15%) were recorded in 21 consecutive patients with stage II peripheral arterial occlusive disease. Heart rate, systolic blood pressure, ankle blood pressure, and ankle/brachial systolic blood pressure ratio (A/B ratio), as well as plasma lactate, plasma hypoxanthine and serum arginine were recorded before and at fifteen to thirty-minute intervals for up to two hours after the treadmill test. Immediately after the treadmill test, lactate levels (36.6 +/- 3.7 mg/L) and hypoxanthine levels (2.73 +/- 0.19 mmol/L) were significantly (p less than 0.001) increased but returned to preexercise levels after thirty and sixty minutes, respectively. Arginine levels did not change significantly. Ankle blood pressure (57 +/- 5 mm Hg) and A/B ratio (0.40 +/- 0.04) were significantly (p less than 0.001) decreased after exercise, while heart rate and systolic blood pressure were increased. These parameters returned to normal as well within a half hour after exercise. Absolute walking distance correlated significantly (p less than 0.01) with the postexercise systolic blood pressure (r = -0.62), ankle pressure (r = 0.63) and A/B ratio (r = 0.72). Induced hypoxanthine and lactate production intercorrelated significantly positively (r = 0.57, p = 0.007) but were independent of the absolute walking distance. In contrast with lactate, hypoxanthine production correlated significantly with postexercise ankle pressure (r = 0.49, p = 0.02) and exercise-induced fall in A/B ratio (r = 0.66, p = 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
D Duprez; M De Buyzere; A Van Wassenhove; D Clement
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Angiology     Volume:  43     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-23     Completed Date:  1992-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  126-33     Citation Subset:  IM    
Department of Cardiology-Angiology, University Hospital of Gent, Belgium.
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MeSH Terms
Arginine / blood
Arterial Occlusive Diseases / blood*,  physiopathology
Blood Pressure
Energy Metabolism*
Exercise Test*
Hypoxanthines / blood
Lactates / blood
Middle Aged
Peripheral Vascular Diseases / blood,  physiopathology
Time Factors
Reg. No./Substance:
0/Hypoxanthines; 0/Lactates; 68-94-0/Hypoxanthine; 74-79-3/Arginine

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