Document Detail

Evaluation of the mercury exposure of dental amalgam patients by the Mercury Triple Test.
MedLine Citation:
PMID:  15150394     Owner:  NLM     Status:  MEDLINE    
AIMS: To establish and analyse reference data for the mercury burden of patients with and without amalgam fillings. METHODS: Atomic absorption spectroscopy was used to quantify Hg concentrations in the scalp hair and urine (before and after application of dimercaptopropane sulphonate), and Hg release from dental amalgams (using a newly developed, amalgam specific chew test), in 2223 subjects. RESULTS: 50th centiles were 1.3 microg Hg/g creatinine in basal urine, 32 microg Hg/g creatinine after DMPS application, 454 ng Hg/g in hair, and 27 microg Hg per g of chewing gum, which corresponds to about 1 micro g Hg released per minute of chewing. Total Hg intake (from ambient air, drinking water, food, and amalgams) of most patients is well below the provisioned tolerable weekly intake (PTWI) defined by the WHO, unless extremely Hg rich food is consumed on a regular basis. However, for patients exceeding the 75th centile in chew tests, total Hg intake exceeds the PTWI by about 50%, even at the low limit of intake from food. In the absence of occupational exposure, significant Hg release from dental amalgams is a necessary but insufficient condition to obtain a high long term body burden. After removal of dental amalgams, chew tests no longer exhibit oral Hg exposure, while basal urine Hg content and DMPS induced excretion display a exponential decrease (half life about 2 months in both cases). CONCLUSIONS: A standardised procedure for evaluation of the magnitude and origin of the Hg burden of individuals has been developed, which, by comparison with the database presented here for the first time, can serve as a diagnostic tool.
G Hansen; R Victor; E Engeldinger; C Schweitzer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  61     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-19     Completed Date:  2004-06-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  535-40     Citation Subset:  IM    
Laboratoire d'Hygiène du Milieu et de Surveillance Biologique, Laboratoire National de Santé, Luxembourg.
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MeSH Terms
Body Burden
Chewing Gum*
Dental Amalgam / chemistry*
Dental Restoration, Permanent
Hair / chemistry
Mercury / urine*
Reproducibility of Results
Unithiol / administration & dosage
Reg. No./Substance:
0/Chewing Gum; 4076-02-2/Unithiol; 7439-97-6/Mercury; 8049-85-2/Dental Amalgam

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