Document Detail


Evaluation of melanin-related metabolites as markers of solar ultraviolet-B radiation.
MedLine Citation:
PMID:  16965276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ultraviolet-B (UVB) radiation due sunlight can result in sunburns and/or suntans. Sunburn occurs only several hours after solar UVB radiation, while a suntan requires several days to several weeks to develop. In the present study, we measured serum and urine levels of melanin-related metabolites, 5-S-cysteinyldopa (5-S-CD) and 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C), in nine subjects exposed to normal sunlight over the course of 12 months. We collected samples in the middle of each month and examined the variation of the markers, the correlation between them, and their correlation with solar UVB radiation. Those markers exhibited a seasonal variation with lower values in the winter and higher values in the summer. Levels of 5-S-CD and 6H5MI2C in the serum showed 48% and 54% increases in the summer compared with those in the winter, respectively. Comparison of 5-S-CD in the serum and urine showed the highest correlation (r2 = 0.344), followed by the pair of 5-S-CD and 6H5MI2C in the serum. Levels of 5-S-CD in the serum showed the highest correlation (r2 = 0.729) with the mean solar UVB radiation during the first 10 d of the month, while 6H5MI2C in the serum was highly correlated (r2 = 0.483) with solar UVB radiation during the previous month. Levels of 5-S-CD and 6H5MI2C in the serum appear to reflect the degrees of skin injury and pigmentation in the skin, respectively.
Authors:
Kazumasa Wakamatsu; Shosuke Ito
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society     Volume:  19     ISSN:  0893-5785     ISO Abbreviation:  Pigment Cell Res.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-12     Completed Date:  2006-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800247     Medline TA:  Pigment Cell Res     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  460-4     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan. kwaka@fujita-hu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood,  urine
Cysteinyldopa / blood*,  urine*
Female
Humans
Indoles / blood*,  urine*
Male
Melanins / blood*,  urine*
Middle Aged
Seasons*
Skin / injuries,  metabolism
Skin Pigmentation / radiation effects
Ultraviolet Rays*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Indoles; 0/Melanins; 19641-92-0/Cysteinyldopa; 2638-99-5/6-hydroxy-5-methoxy-2-indolylcarboxylic acid

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