Document Detail


Evaluation of medigoxin in outpatients.
MedLine Citation:
PMID:  7286028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared our ability to predict the dose of medigoxin and of digoxin required to achieve a fixed serum concentration (the dose requirement) in 33 outpatients. Preliminary work supported the assumptions that the steady state glycoside concentration achieved was proportional to the daily dose given to an individual, and that the bioavailability of the different tablet presentations was similar for either glycoside. We were not able to predict the dose requirement from patient characteristics with any more certainty for medigoxin than for digoxin. Not only the between-patient variability in dose requirement, but also the within-patient variability, was similar for the two glycosides. However the digoxin used had a dissolution rate of over 90% in 1 h. When comparing medigoxin with digoxin of lower, or more variable dissolution rate, medigoxin may be preferable.
Authors:
W R Smith; E M Rodgers; P W Nicholson; R P Humm; D A Gettins; S M Dobbs; A A Deshmukh
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  19     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  251-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Cardiac Glycosides / blood
Digoxin / administration & dosage,  analogs & derivatives*,  metabolism
Drug Evaluation
Female
Humans
Male
Medigoxin / administration & dosage*,  metabolism
Quality Control
Solubility
Tablets
Chemical
Reg. No./Substance:
0/Cardiac Glycosides; 0/Tablets; 20830-75-5/Digoxin; 30685-43-9/Medigoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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