| Evaluation of medication adherence and quality of life in patients with hepatitis C virus receiving combination therapy. | |
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MedLine Citation:
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PMID: 20890160 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The purpose of this study was to identify medication adherence for patients infected with hepatitis C virus (HCV) referred to an interdisciplinary HCV education and monitoring service, evaluate changes in quality of life (QOL) and medication adherence during the first 3 months of HCV therapy, and determine relationships between adherence and QOL. Patients completed an initial survey before initiating the therapy evaluating medication adherence and QOL. They then received a structured training on HCV medications and monthly monitoring phone call from a pharmacist throughout the therapy. After 3 months of treatment, a follow-up survey was conducted to evaluate adherence, satisfaction, and QOL. Medication adherence was also assessed via patient self-report during follow-up phone calls. Patients expressed satisfaction with the care provided by the pharmacist and nurse practitioner individually and working collaboratively during their HCV therapy. Patients reported taking 99.8% of total interferon and ribavirin doses during the first 3 months of the therapy. Patients who indicated that they sometimes stopped taking medication when they felt worse had higher median aggregate physical functioning scores (p = .04) and those with no comorbidities found dosage times more inconvenient than those with at least one comorbidity (p = .046). Patients in a pharmacist-run HCV education service have high self-reported adherence rates and are satisfied with the interdisciplinary model of care. Quality of life may be associated with adherence; higher functioning, healthier patients may be more likely to stop taking HCV medications owing to side effects or inconvenience. |
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Authors:
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Jennifer L Rodis; Pamella Kibbe |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates Volume: 33 ISSN: 1538-9766 ISO Abbreviation: Gastroenterol Nurs Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8915377 Medline TA: Gastroenterol Nurs Country: United States |
Other Details:
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Languages: eng Pagination: 368-73 Citation Subset: N |
Affiliation:
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The Ohio State University College of Pharmacy, Columbus, OH 43210, USA. rodis.2@osu.edu |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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