Document Detail

Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction.
MedLine Citation:
PMID:  18761269     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Using phase analysis of gated single photon emission computed tomography (SPECT) imaging, we examined the relation between myocardial perfusion, degree of electrical dyssynchrony, and degree of SPECT-derived mechanical dyssynchrony in patients with left ventricular (LV) dysfunction.
METHODS AND RESULTS: We retrospectively examined 125 patients with LV dysfunction and ejection fraction of 35% or lower. Fourier analysis converts regional myocardial counts into a continuous thickening function, allowing resolution of phase of onset of myocardial thickening. The SD of LV phase distribution (phase SD) and histogram bandwidth describe LV phase dispersion as a measure of dyssynchrony. Heart failure (HF) patients with perfusion abnormalities have higher degrees of dyssynchrony measured by median phase SD (45.5 degrees vs 27.7 degrees, P < .0001) and bandwidth (117.0 degrees vs 73.0 degrees, P = .0006). HF patients with prolonged QRS durations have higher degrees of dyssynchrony measured by median phase SD (54.1 degrees vs 34.7 degrees, P < .0001) and bandwidth (136.5 degrees vs 99.0 degrees, P = .0005). Mild to moderate correlations exist between QRS duration and phase analysis indices of phase SD (r = 0.50) and bandwidth (r = 0.40). Mechanical dyssynchrony (phase SD >43 degrees) was 43.2%.
CONCLUSIONS: HF patients with perfusion abnormalities or prolonged QRS durations have higher degrees of mechanical dyssynchrony. Gated SPECT myocardial perfusion imaging can quantify myocardial function, perfusion, and dyssynchrony and may help in evaluating patients for cardiac resynchronization therapy.
Mark A Trimble; Salvador Borges-Neto; Emily F Honeycutt; Linda K Shaw; Robert Pagnanelli; Ji Chen; Ami E Iskandrian; Ernest V Garcia; Eric J Velazquez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  15     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-09-01     Completed Date:  2009-04-24     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  663-70     Citation Subset:  IM    
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MeSH Terms
Cardiac Pacing, Artificial / methods
Coronary Artery Disease / diagnosis,  pathology
Echocardiography / methods
Gated Blood-Pool Imaging / methods
Heart Failure / pathology*
Middle Aged
Myocardium / pathology*
Retrospective Studies
Tomography, Emission-Computed, Single-Photon / methods*
Ventricular Dysfunction, Left*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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