Document Detail


Evaluation of a mathematical model for predicting the relationship between protein and energy intakes of low-birth-weight infants and the rate and composition of weight gain.
MedLine Citation:
PMID:  7936823     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A model for predicting the relationship between protein and energy intakes of low-birth-weight (LBW) infants and the rate and composition of weight gain is described. It is based on linear multiple regression equations summarizing the rates of weight gain, nitrogen retention, and energy retention of 101 previously studied LBW infants fed protein intakes ranging from 2.25 to 3.9 g.kg-1.d-1 and concomitant energy intakes ranging from 115 to 147 kcal.kg-1.d-1 plus current theory concerning nutrient retention and body composition. To test the validity of the model, three combinations of protein and energy intake predicted by the model to result in specific rates and compositions of weight gain were fed to 44 LBW infants, and the observed rates of weight gain, protein accretion, and fat accretion were compared with the rates predicted by the model. Differences in these and other outcome variables between two of the groups, the intakes of which differed only in energy, also were compared to provide additional insight into the effect of concomitant energy intake on protein utilization. Across groups, actual outcomes correlated closely with predicted outcomes, supporting the validity of the model for the total population. However, outcomes of individual infants deviated as much as 30% from predicted outcomes; the magnitude of the deviation was independent of birth weight, gestational age, or size for gestational age.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
S Kashyap; K F Schulze; R Ramakrishnan; R B Dell; W C Heird
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  35     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-10-28     Completed Date:  1994-10-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  704-12     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, New York 10032.
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MeSH Terms
Descriptor/Qualifier:
Body Composition / physiology
Dietary Proteins / administration & dosage*
Energy Intake*
Humans
Infant Nutritional Physiological Phenomena
Infant, Low Birth Weight
Infant, Newborn
Linear Models
Mathematics
Models, Biological*
Nitrogen / metabolism
Weight Gain / physiology*
Grant Support
ID/Acronym/Agency:
HD13020/HD/NICHD NIH HHS; HD13063/HD/NICHD NIH HHS; RR00645/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Proteins; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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