Document Detail

Evaluation and management of multinodular goiter.
MedLine Citation:
PMID:  8844728     Owner:  NLM     Status:  MEDLINE    
Nodular goiters are encountered commonly in clinical practice by primary care physicians, endocrinologists, surgeons, and otolaryngologists. Epidemiologic data suggest that in the United States, the incidence of such goiters is approximately 0.1% to 1.5% per year, translating into 250,000 new nodules annually. Nodular goiters are more common in women than in men, with advancing age, and after exposure to external irradiation. These goiters may be asymptomatic, with normal TSH levels (nontoxic), or may be associated with systemic thyrotoxic symptoms (toxic MNG or Plummer's disease). Diagnostic evaluation of patients with nodular goiters consists of clinical evaluation, biochemical testing, FNA, and imaging studies. The serum TSH level is a sensitive and reliable index of thyroid function. FNA results are pivotal to assess cancer risk in patient management for prominent palpable and suspicious nodules. Chest radiography, high-resolution ultrasonography, and computed tomography help to delineate the size and extent of a goiter in evaluating compression symptoms. Indications for treatment in patients with MNG include hyperthyroidism, local compression symptoms attributed to the goiter, cosmesis, and concern about malignancy based on FNA results. The use of levothyroxine suppression therapy to effectively decrease and control MNG size is controversial. Thyroid hormone should not be used, however, in patients with suppressed serum TSH levels, to avoid the development of toxic symptoms. Management of toxic MNG by surgery is well established. Radioiodine is also effective therapy for many of these patients. When treatment is necessary for nontoxic MNG, surgical excision is preferred. Our recommendations are as follows. For patients who have small, nontoxic multinodular goiters that are clinically asymptomatic, who are biochemically euthyroid according to serum TSH levels, and who have prominent palpable or suspicious nodules benign by FNA, yearly evaluation with serum TSH determinations and thyroid palpation is sufficient. Patients with modest but stable MNG size and normal serum TSH levels may also be managed by yearly clinical observation. In this second group, levothyroxine suppression therapy is often unsuccessful and has the potential for untoward effects from exogenous hyperthyroidism. For large nontoxic multinodular goiters with local compression symptoms, the preferred treatment is surgery. In patients with toxic MNG, treatment with either surgery or radioiodine is recommended, although patients with large goiters and large, autonomously functioning nodules become euthyroid more quickly following surgery.
D L Hurley; H Gharib
Related Documents :
7317768 - Propranolol in the surgical treatment of hyperthyroidism, including severely thyrotoxic...
21913918 - Characterization of nonalcoholic fatty liver disease unrelated to the metabolic syndrome.
20205308 - Case report: recurrent severe vomiting due to hyperthyroidism.
21303918 - Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique.
10372628 - Coagulofibrinolytic changes after isolated head injury are not different from those in ...
21529268 - Associations of plasma pentraxin 3 and monocyte chemoattractant protein-1 concentration...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Otolaryngologic clinics of North America     Volume:  29     ISSN:  0030-6665     ISO Abbreviation:  Otolaryngol. Clin. North Am.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-12-17     Completed Date:  1996-12-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0144042     Medline TA:  Otolaryngol Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  527-40     Citation Subset:  IM    
Mayo Medical School, Rochester, Minnesota, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Biopsy, Needle
Diagnostic Imaging
Goiter, Nodular / blood,  diagnosis*,  pathology,  therapy
Radiation Injuries / diagnosis
Sex Factors
Thyroid Gland / radiation effects
Thyrotoxicosis / etiology
Thyrotropin / blood
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines.
Next Document:  Inflammatory thyroid disorders.