Document Detail

Evaluation and management of gastroesophageal reflux and pulmonary disease.
MedLine Citation:
PMID:  8814396     Owner:  NLM     Status:  MEDLINE    
Gastroesophageal reflux and pulmonary disease have become causally associated owing to reports of improved pulmonary function in patients with asthma or stridor following antireflux pharmacotherapy or surgery. Mechanisms by which reflux causes pulmonary disease include direct aspiration and neural reflex arcs. A novel additional mechanism for acute life-threatening episodes implicates increased beta-endorphin levels resulting from acid-mediated esophageal pain in the depression of respiratory drive. Diagnostic modalities used in the evaluation of reflux have often been inadequate to demonstrate a cause-and-effect relationship between reflux and pulmonary disease. Recent studies using multiple site pH-metry have attempted to provide evidence for cause and effect but have achieved mixed results. Aggressive antireflux pharmacotherapy and, sometimes, surgery help those patients with chronic pulmonary disease mediated by gastroesophageal reflux.
J F del Rosario; S R Orenstein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  8     ISSN:  1040-8703     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-01-08     Completed Date:  1997-01-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Division of Pediatric Gastroenterology, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA 15213-2583, USA.
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MeSH Terms
Esophagus / chemistry,  innervation,  physiopathology
Gastroesophageal Reflux / complications*,  diagnosis,  physiopathology,  therapy
Hydrogen-Ion Concentration
Pneumonia, Aspiration / physiopathology
Respiratory Tract Diseases / diagnosis,  etiology*,  physiopathology,  therapy

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