| Evaluation and management of gastroesophageal reflux and pulmonary disease. | |
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MedLine Citation:
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PMID: 8814396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastroesophageal reflux and pulmonary disease have become causally associated owing to reports of improved pulmonary function in patients with asthma or stridor following antireflux pharmacotherapy or surgery. Mechanisms by which reflux causes pulmonary disease include direct aspiration and neural reflex arcs. A novel additional mechanism for acute life-threatening episodes implicates increased beta-endorphin levels resulting from acid-mediated esophageal pain in the depression of respiratory drive. Diagnostic modalities used in the evaluation of reflux have often been inadequate to demonstrate a cause-and-effect relationship between reflux and pulmonary disease. Recent studies using multiple site pH-metry have attempted to provide evidence for cause and effect but have achieved mixed results. Aggressive antireflux pharmacotherapy and, sometimes, surgery help those patients with chronic pulmonary disease mediated by gastroesophageal reflux. |
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Authors:
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J F del Rosario; S R Orenstein |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in pediatrics Volume: 8 ISSN: 1040-8703 ISO Abbreviation: Curr. Opin. Pediatr. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1997-01-08 Completed Date: 1997-01-08 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9000850 Medline TA: Curr Opin Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 209-15 Citation Subset: IM |
Affiliation:
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Division of Pediatric Gastroenterology, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, PA 15213-2583, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Esophagus / chemistry, innervation, physiopathology Gastroesophageal Reflux / complications*, diagnosis, physiopathology, therapy Humans Hydrogen-Ion Concentration Infant Pneumonia, Aspiration / physiopathology Respiratory Tract Diseases / diagnosis, etiology*, physiopathology, therapy |
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