| Evaluation of magnetic resonance vessel size imaging by two-photon laser scanning microscopy. | |
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MedLine Citation:
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PMID: 20373394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MR vessel size imaging (MR-VSI) is increasingly applied to noninvasively assess microvascular properties of tumors and to evaluate tumor response to antiangiogenic treatment. MR-VSI provides measures for the microvessel radius and fractional blood volume of tumor tissue. However, data have not yet been evaluated with three-dimensional microscopy techniques. Therefore, three-dimensional two-photon laser scanning microscopy (TPLSM) was performed to assess microvascular radius and fractional vessel volume in tumor and muscle tissue. TPLSM data displayed a mazelike architecture of the tumor microvasculature and mainly parallel oriented muscle microvessels. For both MR-VSI and TPLSM, a larger vessel radius and fractional blood volume were found in the tumor rim than in the core. The microvessel radius was approximately six times larger in tumor and muscle for MR-VSI than for TPLSM. The tumor blood volume was 4-fold lower with MR-VSI than with TPLSM, whereas muscle blood volume was comparable for both techniques. Differences between the tumor rim, core, and muscle tissue showed similar trends for both MR-VSI and TPLSM parameters. These results indicate that MR-VSI does not provide absolute measures of microvascular morphology; however, it does reflect heterogeneity in microvascular morphology. Hence, MR-VSI may be used to assess differences in microvascular morphology. |
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Authors:
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Kim Douma; Marlies Oostendorp; Dick W Slaaf; Mark J Post; Walter H Backes; Marc A M J van Zandvoort |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 63 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 930-9 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Maastricht University Medical Centre, Maastricht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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pathology* Algorithms Animals Blood Volume Determination / methods* Colorectal Neoplasms / pathology* Contrast Media Dextrans Ferrosoferric Oxide Image Processing, Computer-Assisted Imaging, Three-Dimensional Magnetic Resonance Imaging / methods* Male Mice Microcirculation Microscopy, Confocal / methods* Muscle, Skeletal / blood supply Neovascularization, Pathologic / diagnosis* Photons Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/ferumoxtran-10; 1317-61-9/Ferrosoferric Oxide; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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