| Evaluation of lymphatic function by means of dynamic Gd-BOPTA-enhanced MRL in experimental rabbit limb lymphedema. | |
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MedLine Citation:
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PMID: 20802408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to investigate the value and technical methods of 3D dynamic contrast-enhanced magnetic resonance lymphangiography (MRL) in the assessment of lymphatic anatomy and function in the presence of extremity lymphedema. MATERIAL/METHODS: An improved experimental model of obstructive lymphedema was established in 1 hind limb of 6 New Zealand White rabbits. 3D contrast-enhanced MRL was performed with a 3.0-T MR unit after the intracutaneous injection of Gd-BOPTA into the interdigital webs of the dorsal paws. Maximum-intensity projection (MIP) was used to reconstruct the images of the lymphatic system. The dynamic nodal enhancement in the popliteal fossa and time-signal intensity curves between lymphedematous and contralateral limbs were compared. Morphologic abnormalities of the lymphatic system were also evaluated and compared with lymphoscintigraphy (LSG). RESULTS: 3D dynamic contrast-enhanced MRL images were obtained after the administration of Gd-BOPTA. In the normal limb, the popliteal fossa lymph nodes and their afferent and efferent lymph-collecting vessels were clearly visualized as the Gd tracer was rapidly cleared from the interstitial compartment. In contrast, the Gd tracer accumulated slowly at the prior surgical site in the lymphedematous limb. The nodal enhancement of lymphedematous limbs was significantly less than that of the contralateral limbs (P<0.01). Types of time-signal intensity curves were also significantly different between the 2 groups (P<0.001). CONCLUSIONS: 3D dynamic contrast-enhanced MRL can visualize the precise anatomy of lymphatic vessels and lymph nodes in extremity lymphedema, as well as objectively evaluate the functional status of lymph flow transport. |
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Authors:
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Zhaohua Jiang; Qing Lu; James D Kretlow; Xueqing Hu; Guangdong Zhou; Ningfei Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 16 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-22 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: BR313-9 Citation Subset: IM |
Affiliation:
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Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media / diagnostic use* Extremities / physiopathology*, radiography, radionuclide imaging Lymph Nodes / physiopathology*, radiography, radionuclide imaging Lymphedema / chemically induced, physiopathology*, radiography, radionuclide imaging Lymphography* Magnetic Resonance Angiography* Meglumine / analogs & derivatives*, diagnostic use Organometallic Compounds / diagnostic use* Rabbits Radionuclide Imaging Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 113662-23-0/gadobenic acid; 6284-40-8/Meglumine |
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