| Evaluation of local recurrence after treatment for hepatocellular carcinoma by contrast-enhanced ultrasonography using Sonazoid: comparison with dynamic computed tomography. | |
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MedLine Citation:
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PMID: 20232404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the effectiveness of contrast-enhanced ultrasonography (CEUS) using Sonazoid for the diagnosis of the local recurrence after treatment for hepatocellular carcinoma (HCC) by comparing it with dynamic CT. METHODS: Seventy-one patients with 87 HCC lesions (mean +/- SD; 19.5 +/- 9.6 mm) underwent CEUS using Sonazoid and dynamic CT after radiofrequency ablation (n = 55), transcatheter arterial chemoembolization (n = 22), or radiofrequency ablation combined with transcatheter arterial chemoembolization (n = 10). Two hepatologists (observer 1; 10 years of experience, and 2; 20 years of experience) reviewed the CEUS and dynamic CT images independently and evaluated presence or absence of the local recurrence. Diagnostic performance for the local recurrence was assessed using receiver operating characteristic curve analysis. RESULTS: The Az value for dynamic CT was significantly lower in observer 1 than 2 (p < 0.05). The sensitivity of CEUS was 79% in observer 1 and 83.9% in observer 2, and that of dynamic CT was 83.9% and 90.3%, respectively. The specificity of CEUS was 96%, and that of dynamic CT was 92%, in both observers. CONCLUSION: This study suggests that CEUS using Sonazoid is less affected by the observer's experience and is more accurate in the diagnosis of local recurrence after treatment for HCC than dynamic CT. |
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Authors:
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Kazue Shiozawa; Manabu Watanabe; Ryuji Takayama; Masayoshi Takahashi; Noritaka Wakui; Kazunari Iida; Yasukiyo Sumino |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of clinical ultrasound : JCU Volume: 38 ISSN: 1097-0096 ISO Abbreviation: J Clin Ultrasound Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-07-20 Revised Date: 2011-12-12 |
Medline Journal Info:
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Nlm Unique ID: 0401663 Medline TA: J Clin Ultrasound Country: United States |
Other Details:
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Languages: eng Pagination: 182-9 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology and Hepatology, Toho University Medical Center, Omori Hospital, 6-11-1, Omorinishi, Ota-ku, Tokyo 143-8541, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Area Under Curve Carcinoma, Hepatocellular / radiography, therapy, ultrasonography* Catheter Ablation Chemoembolization, Therapeutic Contrast Media / diagnostic use* Female Ferric Compounds / diagnostic use* Humans Image Enhancement / methods Iron / diagnostic use* Liver / radiography, ultrasonography Liver Neoplasms / radiography, therapy, ultrasonography* Male Middle Aged Neoplasm Recurrence, Local / radiography, ultrasonography* Observer Variation Oxides / diagnostic use* ROC Curve Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Ferric Compounds; 0/Oxides; 0/Sonazoid; 7439-89-6/Iron |
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