Document Detail

Evaluation of liquid-based cytology in cervical screening of high-risk populations: a split study of colposcopy and genito-urinary medicine populations.
MedLine Citation:
PMID:  12060077     Owner:  NLM     Status:  MEDLINE    
A split study evaluated the ThinPrep(R) PapTesttrade mark (TP; Cytyc Corp., Boxborough, MA) compared with current methodologies of cervical cytology in two high-risk cohorts. One thousand, three hundred cases from a colposcopy clinic and a genito-urinary medicine outpatient clinic were examined. The TP reported increased detection of all grades of dyskaryosis (mild, moderate and severe; + 4.5%) and a decrease in borderline and unsuitable cases (- 4.9%). Four cases of high-grade dyskaryosis (moderate or severe) were detected only using the TP, while an additional four cases classified as high-grade dyskaryosis with the TP were reported as borderline by our conventional methods. The split-study finding of increased sensitivity with the TP provides for improved clinical management of patients in our high-risk cohorts.
M Ring; N Bolger; M O'Donnell; A Malkin; N Bermingham; E Akpan; F Mulcahy; M J Turner; M Griffin; J J O'Leary
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Cytopathology : official journal of the British Society for Clinical Cytology     Volume:  13     ISSN:  0956-5507     ISO Abbreviation:  Cytopathology     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-12     Completed Date:  2002-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9010345     Medline TA:  Cytopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  152-9     Citation Subset:  IM    
Department of Cytology, Coombe Women's Hospital, Dublin, Ireland.
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MeSH Terms
Cell Nucleus / pathology
Cohort Studies
Histocytological Preparation Techniques
Ireland / epidemiology
Mass Screening / methods*
Outpatient Clinics, Hospital
Sensitivity and Specificity
Uterine Cervical Neoplasms / diagnosis*,  epidemiology
Vaginal Smears / methods*
Comment In:
Cytopathology. 2003 Feb;14(1):41-2   [PMID:  12588312 ]

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