| Evaluation levels of cytokines in amniotic fluid of women with intrauterine infection in the early second trimester. | |
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MedLine Citation:
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PMID: 16354974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amniotic fluid was obtained from 180 patients by amniocentesis at 16-22 weeks of gestation and assayed for the levels of interleukin (IL)-6, IL-8, leukocyte elastase (LE), and glucose. Ten of cases had clinical symptoms, such as uterine contraction, genital bleeding, and cervical ripening, and the other 170 were assessed for fetal chromosomal features. Four of the ten cases with uterine contraction developed abortion, while 10 of those screened had findings of fetal chromosomal anomalies, and 7 cases then underwent induced abortion artificially. In the cases of abortion, levels of IL-6, IL-8 and LE were higher than in the samples from the 160 pregnant women without clinical symptoms and a normal karyotype, while glucose in amniotic fluid was lower. Of 6 cases with clinical symptoms, but not developing abortion, 4 developed preterm labor, and in these IL-6 and IL-8 also were significantly elevated, with LE being slight high compared to normal. The results suggest that IL-6, IL-8, LE, and glucose in amniotic fluid at early second trimester can be used as markers of severe infection in the uterus, and with the first two being particularly sensitive. |
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Authors:
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Yoshikatsu Suzuki; Tamao Yamamoto; Kazuhisa Kojima; Mitsuyo Tanemura; Hisashi Tateyama; Kaoru Suzumori |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 21 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2006 |
Date Detail:
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Created Date: 2005-12-15 Completed Date: 2006-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 45-50 Citation Subset: IM |
Copyright Information:
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(c) 2006 S. Karger AG, Basel |
Affiliation:
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Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan. og.yo@med.nagoya-cu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Septic
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immunology Amniotic Fluid / metabolism* Biological Markers / metabolism Female Glucose / metabolism Humans Immunohistochemistry Interleukin-6 / analysis, metabolism* Interleukin-8 / metabolism* Leukocyte Elastase / metabolism Placenta / immunology, pathology Pregnancy Pregnancy Complications, Infectious / diagnosis* Pregnancy Trimester, Second Prenatal Diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-6; 0/Interleukin-8; 50-99-7/Glucose; EC 3.4.21.37/Leukocyte Elastase |
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