| Evaluation of lesion in a spontaneous osteonecrosis of the knee using 18F-fluoride positron emission tomography. | |
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MedLine Citation:
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PMID: 18830580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Positron-emission tomography (PET) imaging has several advantages over conventional scintigraphy, including a high spatial resolution and the ability to quantify disease progression. Recently, (18)F-fluoride PET has been applied to the evaluation of malignant tumors and musculoskeletal disorders. In our current study, spontaneous osteonecrosis of the knee (SONK) was visualized using this technique. We determined whether PET images can reveal SONK lesions, whether there were significant differences in the maximum standardized uptake value (SUVmax) among each of the SONK stages, and finally if there was any correlation between the maximum SUVmax value and size of the SONK lesion measured both by radiography and MRI. Fourteen knees from 13 patients diagnosed with SONK were imaged using a PET scanner. In all cases, PET showed an accumulation of 18F-fluoride in the medial condyle. The SUVmax ranged from 8.6 to 23.7 with an average of 15.1 +/- 3.7 and was measured at different disease stages with an average of 12.4 +/- 5.9 in Stage 2 (n = 5), 16.3 +/- 1.4 in Stage 3 (n = 4), and 16.8 +/- 4.3 (n = 5) in Stage 4 lesions. There were no significant differences in these measurements between the SONK stages. However, a significant positive correlation between the SUVmax and lesion size, including the surface area of the lesion (r2 = 0.692, P = 0.0002) and the condyle width ratio (r2 = 0.365, P = 0.022), was found. The approximate volumes of the lesions measured by MRI had an average of 4.8 +/- 3.1 cm3, and also showed a significant correlation with the SUVmax (r2 = 0.853, P < 0.0001). Hence, our present results indicate that a high SUV is indicative of a large SONK lesion. |
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Authors:
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Masato Aratake; Tayama Yoshifumi; Akira Takahashi; Ryohei Takeuchi; Tomio Inoue; Tomoyuki Saito |
Publication Detail:
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Type: Journal Article Date: 2008-10-02 |
Journal Detail:
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Title: Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA Volume: 17 ISSN: 1433-7347 ISO Abbreviation: Knee Surg Sports Traumatol Arthrosc Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-13 Completed Date: 2009-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9314730 Medline TA: Knee Surg Sports Traumatol Arthrosc Country: Germany |
Other Details:
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Languages: eng Pagination: 53-9 Citation Subset: IM |
Affiliation:
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Department of Orthopaedic Surgery, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan. aratake@cj9.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Disease Progression Female Femur / pathology, radiography, radionuclide imaging* Fluorine Radioisotopes / diagnostic use Humans Knee / pathology, radiography, radionuclide imaging* Middle Aged Osteonecrosis / pathology, radiography, radionuclide imaging* Positron-Emission Tomography / methods* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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