Document Detail

Evaluation of the lemon and banana signs in one hundred thirty fetuses with open spina bifida.
MedLine Citation:
PMID:  2178424     Owner:  NLM     Status:  MEDLINE    
The incidence and diagnostic accuracy of the lemon and cerebellar ultrasonographic markers, as well as head size and ventriculomegaly, were evaluated in a study of 1561 patients at high risk for fetal neural tube defects. In the 130 fetuses with open spina bifida there was a relationship between gestational age and the presence of each of these markers. The lemon sign was present in 98% of fetuses at less than or equal to 24 weeks' gestation but in only 13% of those at greater than 24 weeks' gestation. Cerebellar abnormalities were present in 95% of fetuses irrespective of gestation; however, the cerebellar abnormality at less than or equal to 24 weeks' gestation was predominantly the banana sign (72%) whereas at gestations greater than 24 weeks it was cerebellar "absence" (81%). Both growth retardation and cerebral ventriculomegaly significantly worsened with gestation while the head circumference remained disproportionately small throughout gestation. On the basis of these data, a new approach is proposed for the investigation of patients at high risk for fetal open spina bifida.
M C Van den Hof; K H Nicolaides; J Campbell; S Campbell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  162     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-05     Completed Date:  1990-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  322-7     Citation Subset:  AIM; IM    
Harris Birthright Research Centre for Fetal Medicine, King's College School of Medicine, Denmark Hill, London, UK.
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MeSH Terms
Arnold-Chiari Malformation / diagnosis
Brain / abnormalities
Cerebellum / abnormalities*
Fetal Diseases / diagnosis*
Prenatal Diagnosis*
Skull / abnormalities
Spina Bifida Occulta / diagnosis*

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