Document Detail

Evaluation of left ventricular mass measured by 3D echocardiography using magnetic resonance imaging as gold standard.
MedLine Citation:
PMID:  17101557     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Increased left ventricular mass (LVM) and presence of left ventricular hypertrophy (LVH) are predictors of cardiovascular morbidity and mortality, but can be reversed with proper treatment of the underlying cause. Therefore accurate as well as reproducible methods for diagnosis and follow-up are needed. We evaluated different modalities by which to measure LVM in patients with no known LVH using magnetic resonance imaging (MRI) as the gold standard: ECG using the formulae proposed by Sokolow-Lyon and Cornell, 2D echocardiography and 3D echocardiography. METHODS: 34 subjects were included in the study; 17 had a history of myocardial infarction, 7 had pulmonary hypertension and 10 were healthy. All patients and controls had a standard 12-lead ECG, a transthoracic 2D and 3D echocardiographic study and a cardiac MRI. RESULTS: ECG estimates of LVM correlated poorly with LVM by MRI (r = 0.18, NS and 0.16, NS for Sokolow-Lyon and Cornell, respectively), whereas a moderate correlation between 2D and 3D echocardiography and MRI was observed (r = 0.63, p<0.001 and r = 0.74, p<0.001, respectively). All methods were reproducible with no significant bias. CONCLUSION: LVM measured by 3D echocardiography is highly accurate compared to LVM measured by MRI. LVM calculated from 2D echocardiography also proved useful, whereas estimates of LVM by ECG are inaccurate in a non-hypertrophic population.
M Lenstrup; J Kjaergaard; C L Petersen; A Kjaer; C Hassager
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  66     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-14     Completed Date:  2007-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  647-57     Citation Subset:  IM    
Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Denmark.
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MeSH Terms
Echocardiography, Three-Dimensional*
Hypertension, Pulmonary / diagnosis*
Hypertrophy, Left Ventricular / diagnosis*
Magnetic Resonance Imaging*
Myocardial Infarction / diagnosis*
Reference Values
Reproducibility of Results

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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